Lacryglobin in human tears, a potential marker for cancer

Victoria Evans; Cassandra Vockler; Michael Friedlander; Bradley Walsh; Mark D.P. Willcox

doi:10.1046/j.1442-9071.2001.00408.x

Lacryglobin in human tears, a potential marker for cancer

Victoria Evans, Cassandra Vockler, Michael Friedlander, Bradley Walsh, Mark D.P. Willcox

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Lacryglobin has been identified in human tears. This protein has high sequence homology to the mammaglobins, proteins upregulated in breast cancer and in breast cancer metastasis. In order to investigate the utility of tear screening for cancer, tear samples were collected from patients with different types of cancer and compared to controls. Tear samples were taken from five controls and eight breast, six lung, five colon, one prostate and three ovary cancer patients. Tears were analysed using 2-D gel electrophoresis (n = 25) and I-D electrophoresis (n = 3). Lacryglobin was present in the following percentage of patients: breast cancer (88%), lung (83%), colon (100%), ovary (33%), prostate (100%) and controls (60%). Two control patients with lacryglobin had a family history of breast and prostate cancer. Lacryglobin was detected in some but not all tear samples and further studies are warranted to investigate its potential as a marker for cancer.

Original language	English
Pages (from-to)	161-163
Number of pages	3
Journal	Clinical and Experimental Ophthalmology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1046/j.1442-9071.2001.00408.x
Publication status	Published - 2001
Externally published	Yes

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10.1046/j.1442-9071.2001.00408.x

Cite this

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title = "Lacryglobin in human tears, a potential marker for cancer",

abstract = "Lacryglobin has been identified in human tears. This protein has high sequence homology to the mammaglobins, proteins upregulated in breast cancer and in breast cancer metastasis. In order to investigate the utility of tear screening for cancer, tear samples were collected from patients with different types of cancer and compared to controls. Tear samples were taken from five controls and eight breast, six lung, five colon, one prostate and three ovary cancer patients. Tears were analysed using 2-D gel electrophoresis (n = 25) and I-D electrophoresis (n = 3). Lacryglobin was present in the following percentage of patients: breast cancer (88%), lung (83%), colon (100%), ovary (33%), prostate (100%) and controls (60%). Two control patients with lacryglobin had a family history of breast and prostate cancer. Lacryglobin was detected in some but not all tear samples and further studies are warranted to investigate its potential as a marker for cancer.",

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author = "Victoria Evans and Cassandra Vockler and Michael Friedlander and Bradley Walsh and Willcox, {Mark D.P.}",

year = "2001",

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T1 - Lacryglobin in human tears, a potential marker for cancer

AU - Evans, Victoria

AU - Vockler, Cassandra

AU - Friedlander, Michael

AU - Walsh, Bradley

AU - Willcox, Mark D.P.

PY - 2001

Y1 - 2001

N2 - Lacryglobin has been identified in human tears. This protein has high sequence homology to the mammaglobins, proteins upregulated in breast cancer and in breast cancer metastasis. In order to investigate the utility of tear screening for cancer, tear samples were collected from patients with different types of cancer and compared to controls. Tear samples were taken from five controls and eight breast, six lung, five colon, one prostate and three ovary cancer patients. Tears were analysed using 2-D gel electrophoresis (n = 25) and I-D electrophoresis (n = 3). Lacryglobin was present in the following percentage of patients: breast cancer (88%), lung (83%), colon (100%), ovary (33%), prostate (100%) and controls (60%). Two control patients with lacryglobin had a family history of breast and prostate cancer. Lacryglobin was detected in some but not all tear samples and further studies are warranted to investigate its potential as a marker for cancer.

AB - Lacryglobin has been identified in human tears. This protein has high sequence homology to the mammaglobins, proteins upregulated in breast cancer and in breast cancer metastasis. In order to investigate the utility of tear screening for cancer, tear samples were collected from patients with different types of cancer and compared to controls. Tear samples were taken from five controls and eight breast, six lung, five colon, one prostate and three ovary cancer patients. Tears were analysed using 2-D gel electrophoresis (n = 25) and I-D electrophoresis (n = 3). Lacryglobin was present in the following percentage of patients: breast cancer (88%), lung (83%), colon (100%), ovary (33%), prostate (100%) and controls (60%). Two control patients with lacryglobin had a family history of breast and prostate cancer. Lacryglobin was detected in some but not all tear samples and further studies are warranted to investigate its potential as a marker for cancer.

KW - Cancer

KW - Lacryglobin

KW - Mammaglobin

KW - Tears

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DO - 10.1046/j.1442-9071.2001.00408.x

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JO - Clinical and Experimental Ophthalmology

JF - Clinical and Experimental Ophthalmology

IS - 3

ER -

Lacryglobin in human tears, a potential marker for cancer

Abstract

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