Latent Class Analysis to identify clinical profiles among Indigenous infants with bronchiolitis

Hongqi Niu, Anne Bernadette Chang, Victor M Oguoma, Zhiqiang Wang, Gabrielle Britt Mccallum

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
44 Downloads (Pure)


Objective: Better phenotyping of the heterogenous bronchiolitis syndrome may lead to targeted future interventions. This study aims to identify severe bronchiolitis profiles among hospitalized Australian Indigenous infants, a population at risk of bronchiectasis, using latent class analysis (LCA). Methods: We included prospectively collected clinical, viral, and nasopharyngeal bacteria data from 164 Indigenous infants hospitalized with bronchiolitis from our previous studies. We undertook multiple correspondence analysis (MCA) followed by LCA. The best-fitting model for LCA was based on adjusted Bayesian information criteria and entropy R 2. Results: We identified five clinical profiles. Profile-A's (23.8% of cohort) phenotype was previous preterm (90.7%), low birth-weight (89.2%) and weight-for-length z-score <−1 (82.7% from combining those with z-score between −1 and −2 and those in the z-score of <−2 group) previous respiratory hospitalization (39.6%) and bronchiectasis on chest high-resolution computed tomography scan (35.4%). Profile-B (25.3%) was characterized by the oxygen requirement (100%) and marked accessory muscle use (45.5%). Infants in profile-C (7.0%) had the most severe disease, with oxygen requirement and bronchiectasis in 100%, moderate accessory muscle use (85% vs 0%-51.4%) and bacteria detected (93.1% vs 56.7%-72.0%). Profile-D (11.6%) was dominated by rhinovirus (49.4%), mild accessory muscle use (73.8%), and weight-for-length z-score <−2 (36.0%). Profile-E (32.2%) included bronchiectasis (13.8%), RSV (44.0%), rhinovirus (26.3%) and any bacteria (72%). Conclusion: Using LCA in Indigenous infants with severe bronchiolitis, we identified five clinical profiles with one distinct profile for bronchiectasis. LCA can characterize distinct phenotypes for severe bronchiolitis and infants at risk for future bronchiectasis, which may inform future targeted interventions.

Original languageEnglish
Pages (from-to)3096-3103
Number of pages8
JournalPediatric Pulmonology
Issue number11
Publication statusPublished - 1 Nov 2020
Externally publishedYes


Dive into the research topics of 'Latent Class Analysis to identify clinical profiles among Indigenous infants with bronchiolitis'. Together they form a unique fingerprint.

Cite this