Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults

The ATTICA study

Ioannis Kyrou, Demosthenes B. Panagiotakos, Georgia Maria Kouli, Ekavi Georgousopoulou, Christina Chrysohoou, Constantine Tsigos, Dimitrios Tousoulis, Christos Pitsavos

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and aims: The lipid accumulation product (LAP) is an index describing lipid over-accumulation based on waist circumference (WC) and fasting triglycerides, and can outperform the body mass index (BMI) in recognizing cardiovascular disease (CVD) risk. We aimed to explore the association of LAP with long-term CVD risk and compare its CVD-predictive value against common anthropometric indices/ratios of obesity. Methods: ATTICA is a prospective, population-based cohort that recruited 3042 adults without pre-existing CVD from the Greek general population (age 18–89 years; 1514 men). The 10-year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). Baseline LAP (cm·mmol/L) was calculated and analyzed in relation to the 10-year CVD incidence. Results: In total, 317 CVD cases (15.7%) were documented during the follow-up. Baseline LAP showed a significant positive association with the 10-year CVD incidence, even after adjusting for hypertension, diabetes, hypercholesterolemia, smoking, physical activity, Mediterranean diet adherence, and key pro-inflammatory biomarkers (Hazard Ratios per 10 cm·mmol/L of LAP ranging from 1.1 to 1.21, p = 0.04). Moreover, LAP predicted the 10-year CVD study incidence better than common obesity indices (BMI, WC, waist-to-hip, waist-to-height ratio). Conclusions: These findings support a positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults from the general population.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalAtherosclerosis
Volume279
DOIs
Publication statusPublished - 1 Dec 2018

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Lipid Accumulation Product
Cardiovascular Diseases
Incidence
Waist Circumference
Body Mass Index
Obesity
Population
Mediterranean Diet
Preexisting Condition Coverage

Cite this

Kyrou, I., Panagiotakos, D. B., Kouli, G. M., Georgousopoulou, E., Chrysohoou, C., Tsigos, C., ... Pitsavos, C. (2018). Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults: The ATTICA study. Atherosclerosis, 279, 10-16. https://doi.org/10.1016/j.atherosclerosis.2018.10.015
Kyrou, Ioannis ; Panagiotakos, Demosthenes B. ; Kouli, Georgia Maria ; Georgousopoulou, Ekavi ; Chrysohoou, Christina ; Tsigos, Constantine ; Tousoulis, Dimitrios ; Pitsavos, Christos. / Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults : The ATTICA study. In: Atherosclerosis. 2018 ; Vol. 279. pp. 10-16.
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abstract = "Background and aims: The lipid accumulation product (LAP) is an index describing lipid over-accumulation based on waist circumference (WC) and fasting triglycerides, and can outperform the body mass index (BMI) in recognizing cardiovascular disease (CVD) risk. We aimed to explore the association of LAP with long-term CVD risk and compare its CVD-predictive value against common anthropometric indices/ratios of obesity. Methods: ATTICA is a prospective, population-based cohort that recruited 3042 adults without pre-existing CVD from the Greek general population (age 18–89 years; 1514 men). The 10-year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50{\%} men). Baseline LAP (cm·mmol/L) was calculated and analyzed in relation to the 10-year CVD incidence. Results: In total, 317 CVD cases (15.7{\%}) were documented during the follow-up. Baseline LAP showed a significant positive association with the 10-year CVD incidence, even after adjusting for hypertension, diabetes, hypercholesterolemia, smoking, physical activity, Mediterranean diet adherence, and key pro-inflammatory biomarkers (Hazard Ratios per 10 cm·mmol/L of LAP ranging from 1.1 to 1.21, p = 0.04). Moreover, LAP predicted the 10-year CVD study incidence better than common obesity indices (BMI, WC, waist-to-hip, waist-to-height ratio). Conclusions: These findings support a positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults from the general population.",
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Kyrou, I, Panagiotakos, DB, Kouli, GM, Georgousopoulou, E, Chrysohoou, C, Tsigos, C, Tousoulis, D & Pitsavos, C 2018, 'Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults: The ATTICA study', Atherosclerosis, vol. 279, pp. 10-16. https://doi.org/10.1016/j.atherosclerosis.2018.10.015

Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults : The ATTICA study. / Kyrou, Ioannis; Panagiotakos, Demosthenes B.; Kouli, Georgia Maria; Georgousopoulou, Ekavi; Chrysohoou, Christina; Tsigos, Constantine; Tousoulis, Dimitrios; Pitsavos, Christos.

In: Atherosclerosis, Vol. 279, 01.12.2018, p. 10-16.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults

T2 - The ATTICA study

AU - Kyrou, Ioannis

AU - Panagiotakos, Demosthenes B.

AU - Kouli, Georgia Maria

AU - Georgousopoulou, Ekavi

AU - Chrysohoou, Christina

AU - Tsigos, Constantine

AU - Tousoulis, Dimitrios

AU - Pitsavos, Christos

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background and aims: The lipid accumulation product (LAP) is an index describing lipid over-accumulation based on waist circumference (WC) and fasting triglycerides, and can outperform the body mass index (BMI) in recognizing cardiovascular disease (CVD) risk. We aimed to explore the association of LAP with long-term CVD risk and compare its CVD-predictive value against common anthropometric indices/ratios of obesity. Methods: ATTICA is a prospective, population-based cohort that recruited 3042 adults without pre-existing CVD from the Greek general population (age 18–89 years; 1514 men). The 10-year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). Baseline LAP (cm·mmol/L) was calculated and analyzed in relation to the 10-year CVD incidence. Results: In total, 317 CVD cases (15.7%) were documented during the follow-up. Baseline LAP showed a significant positive association with the 10-year CVD incidence, even after adjusting for hypertension, diabetes, hypercholesterolemia, smoking, physical activity, Mediterranean diet adherence, and key pro-inflammatory biomarkers (Hazard Ratios per 10 cm·mmol/L of LAP ranging from 1.1 to 1.21, p = 0.04). Moreover, LAP predicted the 10-year CVD study incidence better than common obesity indices (BMI, WC, waist-to-hip, waist-to-height ratio). Conclusions: These findings support a positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults from the general population.

AB - Background and aims: The lipid accumulation product (LAP) is an index describing lipid over-accumulation based on waist circumference (WC) and fasting triglycerides, and can outperform the body mass index (BMI) in recognizing cardiovascular disease (CVD) risk. We aimed to explore the association of LAP with long-term CVD risk and compare its CVD-predictive value against common anthropometric indices/ratios of obesity. Methods: ATTICA is a prospective, population-based cohort that recruited 3042 adults without pre-existing CVD from the Greek general population (age 18–89 years; 1514 men). The 10-year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). Baseline LAP (cm·mmol/L) was calculated and analyzed in relation to the 10-year CVD incidence. Results: In total, 317 CVD cases (15.7%) were documented during the follow-up. Baseline LAP showed a significant positive association with the 10-year CVD incidence, even after adjusting for hypertension, diabetes, hypercholesterolemia, smoking, physical activity, Mediterranean diet adherence, and key pro-inflammatory biomarkers (Hazard Ratios per 10 cm·mmol/L of LAP ranging from 1.1 to 1.21, p = 0.04). Moreover, LAP predicted the 10-year CVD study incidence better than common obesity indices (BMI, WC, waist-to-hip, waist-to-height ratio). Conclusions: These findings support a positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults from the general population.

KW - ATTICA study

KW - Cardiovascular disease

KW - CVD risk

KW - LAP

KW - Lipid accumulation product

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