TY - JOUR
T1 - Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults
T2 - The ATTICA study
AU - Kyrou, Ioannis
AU - Panagiotakos, Demosthenes B.
AU - Kouli, Georgia Maria
AU - Georgousopoulou, Ekavi
AU - Chrysohoou, Christina
AU - Tsigos, Constantine
AU - Tousoulis, Dimitrios
AU - Pitsavos, Christos
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Background and aims: The lipid accumulation product (LAP) is an index describing lipid over-accumulation based on waist circumference (WC) and fasting triglycerides, and can outperform the body mass index (BMI) in recognizing cardiovascular disease (CVD) risk. We aimed to explore the association of LAP with long-term CVD risk and compare its CVD-predictive value against common anthropometric indices/ratios of obesity. Methods: ATTICA is a prospective, population-based cohort that recruited 3042 adults without pre-existing CVD from the Greek general population (age 18–89 years; 1514 men). The 10-year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). Baseline LAP (cm·mmol/L) was calculated and analyzed in relation to the 10-year CVD incidence. Results: In total, 317 CVD cases (15.7%) were documented during the follow-up. Baseline LAP showed a significant positive association with the 10-year CVD incidence, even after adjusting for hypertension, diabetes, hypercholesterolemia, smoking, physical activity, Mediterranean diet adherence, and key pro-inflammatory biomarkers (Hazard Ratios per 10 cm·mmol/L of LAP ranging from 1.1 to 1.21, p = 0.04). Moreover, LAP predicted the 10-year CVD study incidence better than common obesity indices (BMI, WC, waist-to-hip, waist-to-height ratio). Conclusions: These findings support a positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults from the general population.
AB - Background and aims: The lipid accumulation product (LAP) is an index describing lipid over-accumulation based on waist circumference (WC) and fasting triglycerides, and can outperform the body mass index (BMI) in recognizing cardiovascular disease (CVD) risk. We aimed to explore the association of LAP with long-term CVD risk and compare its CVD-predictive value against common anthropometric indices/ratios of obesity. Methods: ATTICA is a prospective, population-based cohort that recruited 3042 adults without pre-existing CVD from the Greek general population (age 18–89 years; 1514 men). The 10-year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). Baseline LAP (cm·mmol/L) was calculated and analyzed in relation to the 10-year CVD incidence. Results: In total, 317 CVD cases (15.7%) were documented during the follow-up. Baseline LAP showed a significant positive association with the 10-year CVD incidence, even after adjusting for hypertension, diabetes, hypercholesterolemia, smoking, physical activity, Mediterranean diet adherence, and key pro-inflammatory biomarkers (Hazard Ratios per 10 cm·mmol/L of LAP ranging from 1.1 to 1.21, p = 0.04). Moreover, LAP predicted the 10-year CVD study incidence better than common obesity indices (BMI, WC, waist-to-hip, waist-to-height ratio). Conclusions: These findings support a positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults from the general population.
KW - ATTICA study
KW - Cardiovascular disease
KW - CVD risk
KW - LAP
KW - Lipid accumulation product
UR - http://www.scopus.com/inward/record.url?scp=85055163694&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2018.10.015
DO - 10.1016/j.atherosclerosis.2018.10.015
M3 - Article
C2 - 30366186
AN - SCOPUS:85055163694
SN - 0021-9150
VL - 279
SP - 10
EP - 16
JO - Atherosclerosis
JF - Atherosclerosis
ER -