Longitudinal studies of cardiac troponin I in a large cohort of healthy children

Gus Koerbin, Julia Potter, W Abhayaratna, Richard Telford, Tony Badrick, Fred S. Apple, Allan S. Jaffe, Peter Hickman

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    32 Citations (Scopus)

    Abstract

    BACKGROUND
    There is little information available on cardiac troponin concentrations in healthy young children.

    METHODS
    Using a precommercial high-sensitivity assay from Abbott Diagnostics, we measured cardiac troponin I (cTnI) in longitudinal blood samples collected at ages 8, 10, and 12 years from a cohort of healthy, community-dwelling children. The 99th percentile values were calculated and estimates of the long-term biological variation were made.

    RESULTS
    cTnI concentrations were above the limit of detection in 87%, 90%, and 98% of the children at ages 8, 10, and 12 years. The 99th percentiles were lower compared to a healthy adult population in both male and female children at all ages studied. At the 3 periods of study assessment, different children had cTnI concentrations above the 99th percentile. The calculated 99th percentile varied markedly depending upon whether the lowest or highest cTnI measurement for an individual child was included in the calculation. Biological variation varied markedly between 0% and 136%, the index of individuality was low at 0.36, and the reference change value was an increase of 147% or a decrease of 59%.

    CONCLUSIONS
    In this longitudinal study of cTnI concentrations in healthy children as determined by a high-sensitivity assay, different children had concentrations of cTnI above the 99th percentile at the 3 episodes of assessment. These results suggest that in children the 99th percentile may not be a reliable index of silent cardiac disease, but rather may be indicating low-grade intercurrent illness.
    Original languageEnglish
    Pages (from-to)1665-1672
    Number of pages8
    JournalClinical Chemistry
    Volume58
    Issue number12
    DOIs
    Publication statusPublished - 2012

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