Low glycaemic index diets as an intervention for obesity: a systematic review and meta-analysis

M. I. Zafar, K. E. Mills, J. Zheng, M. M. Peng, X. Ye, L. L. Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Low glycaemic index (GI) diets may aid in weight loss by reducing postprandial blood glucose excursions, leading to more stable blood glucose concentrations and therefore a reduction in hunger. To test this hypothesis, we conducted a systematic review and meta-analysis of randomized controlled trials comparing low GI diets with other diet types. Methods: We included 101 studies involving 109 study arms and 8,527 participants. We meta-analysed the studies using a random-effects model and conducted subgroup analyses and meta-regression based on control diet, blood glucose control, baseline BMI and dietary GI. Results: Low GI diets resulted in small but significant improvements in body weight, BMI, LDL and total cholesterol overall, although no individual control diet was significantly different from low GI diets. Studies in people with normal blood glucose who achieved a difference in GI of 20 points or more resulted in a larger reduction in body weight (SMD = −0.26; 95% CIs [−0.43, −0.09]), and total cholesterol (SMD = −0.24; 95% CIs [−0.42, −0.05]) than studies that only achieved a smaller reduction in GI. Conclusions: Low GI diets, especially diets achieving a substantial decrease in GI, were moderately effective in lowering body weight. However, efforts should be made to increase compliance with low GI diets, in order for them to be effective in people with overweight and obesity.

Original languageEnglish
Pages (from-to)290-315
Number of pages26
JournalObesity Reviews
Volume20
Issue number2
Early online date20 Nov 2018
DOIs
Publication statusPublished - 1 Feb 2019

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Glycemic Index
Meta-Analysis
Obesity
Diet
Blood Glucose
Body Weight
Hunger
LDL Cholesterol
Weight Loss
Randomized Controlled Trials
Cholesterol
Regression Analysis

Cite this

Zafar, M. I., Mills, K. E., Zheng, J., Peng, M. M., Ye, X., & Chen, L. L. (2019). Low glycaemic index diets as an intervention for obesity: a systematic review and meta-analysis. Obesity Reviews, 20(2), 290-315. https://doi.org/10.1111/obr.12791
Zafar, M. I. ; Mills, K. E. ; Zheng, J. ; Peng, M. M. ; Ye, X. ; Chen, L. L. / Low glycaemic index diets as an intervention for obesity: a systematic review and meta-analysis. In: Obesity Reviews. 2019 ; Vol. 20, No. 2. pp. 290-315.
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Zafar, MI, Mills, KE, Zheng, J, Peng, MM, Ye, X & Chen, LL 2019, 'Low glycaemic index diets as an intervention for obesity: a systematic review and meta-analysis', Obesity Reviews, vol. 20, no. 2, pp. 290-315. https://doi.org/10.1111/obr.12791

Low glycaemic index diets as an intervention for obesity: a systematic review and meta-analysis. / Zafar, M. I.; Mills, K. E.; Zheng, J.; Peng, M. M.; Ye, X.; Chen, L. L.

In: Obesity Reviews, Vol. 20, No. 2, 01.02.2019, p. 290-315.

Research output: Contribution to journalArticle

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AU - Mills, K. E.

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AU - Chen, L. L.

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