Meatal cleaning: discrepancies in need of explanation - Authors' reply

Allen C. Cheng, Brett G. Mitchell, Oyebola Fasugba, Nicholas Graves, Jane Koerner, Peter Collignon

    Research output: Contribution to journalLetterpeer-review


    We thank Johannes C van der Wouden and Ivo Smeele for their interest in our study. The differences in the reported estimates of effect can be explained by the statistical methods used in the analysis.
    The primary analysis that was specified in our study protocol was based on aggregated weekly rates of catheter-associated asymptomatic bacteriuria and catheter-associated urinary tract infection (UTI).1 This is analogous to performing piecemeal interrupted time-series analyses using Poisson regression on multiple time series, with the intervention effect estimated by the step at the time of crossover. In this statistical model, calendar time was included as a covariate and hospital and intervention as fixed effects. As noted in figures 2 and 3 of the Article, an increasing pre-intervention trend might have exaggerated the impact of the intervention.1
    Original languageEnglish
    Pages (from-to)1165-1165
    Number of pages1
    JournalThe Lancet Infectious Diseases
    Issue number11
    Publication statusPublished - Nov 2019


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