Mechanisms underlying T cell immunosenescence: Aging and cytomegalovirus infection

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Abstract

The ability of the human immune system to protect against infectious disease declines with age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune system, also termed as immunosenescence, involves many changes in human T cell immunity that is characterized by a loss in naïve T cell population and an increase in highly differentiated CD28-memory T cell subset. There is extensive data showing that latent persistent human cytomegalovirus (HCMV) infection is also associated with age-related immune dysfunction in the T cells, which might enhance immunosenescence. Understanding the molecular mechanisms underlying age-related and HCMV-related immunosenescence is critical for the development of effective age-targeted vaccines and immunotherapies. In this review, we will address the role of both aging and HCMV infection that contribute to the T cell senescence and discuss the potential molecular mechanisms in aged T cells.
Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalFrontiers in Microbiology
Volume7
Issue numberDEC
DOIs
Publication statusPublished - 2016

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Cell Aging
Cytomegalovirus Infections
T-Lymphocytes
Immune System
T-Lymphocyte Subsets
Cytomegalovirus
Immunotherapy
Communicable Diseases
Immunity
Vaccination
Vaccines
Immunosenescence
Population

Cite this

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title = "Mechanisms underlying T cell immunosenescence: Aging and cytomegalovirus infection",
abstract = "The ability of the human immune system to protect against infectious disease declines with age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune system, also termed as immunosenescence, involves many changes in human T cell immunity that is characterized by a loss in na{\"i}ve T cell population and an increase in highly differentiated CD28-memory T cell subset. There is extensive data showing that latent persistent human cytomegalovirus (HCMV) infection is also associated with age-related immune dysfunction in the T cells, which might enhance immunosenescence. Understanding the molecular mechanisms underlying age-related and HCMV-related immunosenescence is critical for the development of effective age-targeted vaccines and immunotherapies. In this review, we will address the role of both aging and HCMV infection that contribute to the T cell senescence and discuss the potential molecular mechanisms in aged T cells.",
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Mechanisms underlying T cell immunosenescence: Aging and cytomegalovirus infection. / TU, Sherry; RAO, Sudha.

In: Frontiers in Microbiology, Vol. 7, No. DEC, 2016, p. 1-12.

Research output: Contribution to journalArticle

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AB - The ability of the human immune system to protect against infectious disease declines with age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune system, also termed as immunosenescence, involves many changes in human T cell immunity that is characterized by a loss in naïve T cell population and an increase in highly differentiated CD28-memory T cell subset. There is extensive data showing that latent persistent human cytomegalovirus (HCMV) infection is also associated with age-related immune dysfunction in the T cells, which might enhance immunosenescence. Understanding the molecular mechanisms underlying age-related and HCMV-related immunosenescence is critical for the development of effective age-targeted vaccines and immunotherapies. In this review, we will address the role of both aging and HCMV infection that contribute to the T cell senescence and discuss the potential molecular mechanisms in aged T cells.

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