Mechanisms underlying T cell immunosenescence: Aging and cytomegalovirus infection

Sherry TU, Sudha RAO

Research output: Contribution to journalArticle

65 Citations (Scopus)
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Abstract

The ability of the human immune system to protect against infectious disease declines with age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune system, also termed as immunosenescence, involves many changes in human T cell immunity that is characterized by a loss in naïve T cell population and an increase in highly differentiated CD28-memory T cell subset. There is extensive data showing that latent persistent human cytomegalovirus (HCMV) infection is also associated with age-related immune dysfunction in the T cells, which might enhance immunosenescence. Understanding the molecular mechanisms underlying age-related and HCMV-related immunosenescence is critical for the development of effective age-targeted vaccines and immunotherapies. In this review, we will address the role of both aging and HCMV infection that contribute to the T cell senescence and discuss the potential molecular mechanisms in aged T cells.
Original languageEnglish
Article number2111
Pages (from-to)1-12
Number of pages12
JournalFrontiers in Microbiology
Volume7
Issue numberDEC
DOIs
Publication statusPublished - 2016

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