Mediation and modification of the association between hopelessness, hostility, and progression of carotid atherosclerosis

Ricardo A. Pollitt, Mark Daniel, Jay S. Kaufman, John W. Lynch, Jukka T. Salonen, George A. Kaplan

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Hopelessness and hostility are linked to progression of carotid atherosclerosis (PCA). The purpose of this study was to replicate such relations and to evaluate the role of biological pathways involving hyperactivation of the sympathetic nervous system (SNS) and the hypothalamic-pituitary- adrenocortical (HPA) axis. PCA was evaluated by 4-year change in three ultrasound measures of intima-media thickness (IMT) in 1027 men aged 42-60 years at baseline. Effect modification and mediation of relationships between psychosocial factors and PCA were examined for the measures systolic blood pressure (SBP), fibrinogen, and waist-to-hip ratio (WHR), levels of which are indicative of activity along these pathways. Hopelessness and hostility were associated with PCA. Fibrinogen mediated to a moderate extent the association between hopelessness and PCA. SBP significantly modified the relation between hostility and PCA in participants of moderate hostility. The above biological pathways are implicated in the mechanisms connecting hopelessness, hostility, and PCA.

Original languageEnglish
Pages (from-to)53-64
Number of pages12
JournalJournal of Behavioral Medicine
Volume28
Issue number1
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

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Carotid Artery Diseases
Hostility
Blood Pressure
Fibrinogen
Waist-Hip Ratio
Sympathetic Nervous System
Psychology

Cite this

Pollitt, Ricardo A. ; Daniel, Mark ; Kaufman, Jay S. ; Lynch, John W. ; Salonen, Jukka T. ; Kaplan, George A. / Mediation and modification of the association between hopelessness, hostility, and progression of carotid atherosclerosis. In: Journal of Behavioral Medicine. 2005 ; Vol. 28, No. 1. pp. 53-64.
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Mediation and modification of the association between hopelessness, hostility, and progression of carotid atherosclerosis. / Pollitt, Ricardo A.; Daniel, Mark; Kaufman, Jay S.; Lynch, John W.; Salonen, Jukka T.; Kaplan, George A.

In: Journal of Behavioral Medicine, Vol. 28, No. 1, 02.2005, p. 53-64.

Research output: Contribution to journalArticle

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