TY - JOUR
T1 - Mediterranean diet and 10-year (2002-2012) incidence of diabetes and cardiovascular disease in participants with prediabetes
T2 - The ATTICA study
AU - the ATTICA Study group
AU - Filippatos, Theodosios D.
AU - Panagiotakos, Demosthenes B.
AU - Georgousopoulou, Ekavi N.
AU - Pitaraki, Evangelia
AU - Kouli, Georgia Maria
AU - Chrysohoou, Christina
AU - Tousoulis, Dimitrios
AU - Stefanadis, Christodoulos
AU - Pitsavos, Christos
AU - Skoumas, Yannis
AU - Katinioti, Natassa
AU - Papadimitriou, Labros
AU - Masoura, Constantina
AU - Vellas, Spiros
AU - Lentzas, Yannis
AU - Kambaxis, Manolis
AU - Palliou, Konstadina
AU - Metaxa, Vassiliki
AU - Ntzouvani, Agathi
AU - Mpougatsas, Dimitris
AU - Skourlis, Nikolaos
AU - Papanikolaou, Christina
AU - Kouli, Georgia Maria
AU - Christou, Aimilia
AU - Zana, Adella
AU - Ntertimani, Maria
AU - Kalogeropoulou, Aikaterini
AU - Pitaraki, Evangelia
AU - Laskaris, Alexandros
AU - Hatzigeorgiou, Mihail
AU - Grekas, Athanasios
AU - Vassiliadou, Carmen
AU - Dedoussis, George
AU - Toutouza-Giotsa, Marina
AU - Tselika, Constadina
AU - Poulopoulou, Sia
AU - Toutouza, Maria
N1 - Publisher Copyright:
© by Lab & Life Press/SBDR.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - BACKGROUND: Prediabetes has been related to an increased risk of developing diabetes and cardiovascular disease (CVD). AIM: The aim of the present study was to examine the effect of the Mediterranean diet on diabetes and CVD risk in subjects with impaired fasting glucose (IFG, i.e. fasting plasma glucose 100-125 mg/dl). METHODS: During 2001-2002, 3042 men and women (>18y) were enrolled for the study. The participants showed no clinical evidence of CVD or any other chronic disease, and were living in the greater Athens (Greece) area. In 2011 and 2012, the 10-year follow-up examinations were performed, including a working sample of n = 1875 participants without diabetes at baseline. Adherence to the Mediterranean diet at baseline evaluation was assessed using the MedDietScore (range 0-55). RESULTS: The prediabetic subjects (n = 343) had a significantly higher incidence of diabetes (25% vs. 10%, p < 0.001) and CVD (17.8% vs. 12.3%, p = 0.007) compared with subjects with normal glucose values. A significant trend towards lower diabetes and CVD incidence was observed with medium and high adherence to the Mediterranean diet compared with low adherence (p < 0.001). High adherence to the Mediterranean diet (>35/55 score) was associated with lower 10-year incidence of diabetes and CVD. In multiple logistic regression models, participants with high levels of adherence to the Mediterranean diet were significantly less affected by diabetes and CVD than those with low adherence levels. CONCLUSION: High adherence to the Mediterranean diet is associated with a low risk of developing diabetes and CVD in prediabetic subjects.
AB - BACKGROUND: Prediabetes has been related to an increased risk of developing diabetes and cardiovascular disease (CVD). AIM: The aim of the present study was to examine the effect of the Mediterranean diet on diabetes and CVD risk in subjects with impaired fasting glucose (IFG, i.e. fasting plasma glucose 100-125 mg/dl). METHODS: During 2001-2002, 3042 men and women (>18y) were enrolled for the study. The participants showed no clinical evidence of CVD or any other chronic disease, and were living in the greater Athens (Greece) area. In 2011 and 2012, the 10-year follow-up examinations were performed, including a working sample of n = 1875 participants without diabetes at baseline. Adherence to the Mediterranean diet at baseline evaluation was assessed using the MedDietScore (range 0-55). RESULTS: The prediabetic subjects (n = 343) had a significantly higher incidence of diabetes (25% vs. 10%, p < 0.001) and CVD (17.8% vs. 12.3%, p = 0.007) compared with subjects with normal glucose values. A significant trend towards lower diabetes and CVD incidence was observed with medium and high adherence to the Mediterranean diet compared with low adherence (p < 0.001). High adherence to the Mediterranean diet (>35/55 score) was associated with lower 10-year incidence of diabetes and CVD. In multiple logistic regression models, participants with high levels of adherence to the Mediterranean diet were significantly less affected by diabetes and CVD than those with low adherence levels. CONCLUSION: High adherence to the Mediterranean diet is associated with a low risk of developing diabetes and CVD in prediabetic subjects.
KW - Cardiovascular disease
KW - Diabetes incidence
KW - Impaired fasting glucose
KW - Mediterranean diet
KW - Prediabetes
UR - http://www.scopus.com/inward/record.url?scp=85014236276&partnerID=8YFLogxK
U2 - 10.1900/RDS.2016.13.226
DO - 10.1900/RDS.2016.13.226
M3 - Review article
C2 - 28278309
AN - SCOPUS:85014236276
SN - 1613-6071
VL - 13
SP - 226
EP - 235
JO - Review of Diabetic Studies
JF - Review of Diabetic Studies
IS - 4
ER -