MHC haplotypes and response to immunocontraceptive vaccines in the brushtail possum

Olivia Holland, P Cowan, Dianne Gleeson, Janine Duckworth, Larry Chamley

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    The possum is a major invasive pest in New Zealand. One option for its control is the use of immunocontraceptive vaccines. Initial trials of vaccines have shown individual variation in response. The use of vaccines on wild populations could result in the evolution of a resistant population through selection for possums that remain fertile because of low or no response. Understanding the basis of this variation is therefore important. The major histocompatibility complex (MHC) is an important influence on the nature of immune responses. This study has investigated the relationship between MHCalleles and individual immune responses to immunocontraceptive vaccines comprising zona pellucida peptides.We identified MHC alleles and putative haplotypes, and compared these between individuals with measured responses to immunocontraceptive vaccines. Two haplotypes were found to associate significantly with differences in vaccine response. Possums that carried haplotype 6 showed reduced responsiveness to one vaccine, while possums that carried haplotype 9 showed increased responsiveness to a separate vaccine. The identification of MHC haplotypes associated with different responses to immunocontraceptive vaccines offers the opportunity to understand what factors trigger non-response and the persistence of fertility in some individuals, and may allow vaccines to be optimised to minimise non-responsiveness.
    Original languageEnglish
    Pages (from-to)57-65
    Number of pages9
    JournalJournal of Reproductive Immunology
    Volume82
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Major Histocompatibility Complex
    Haplotypes
    Vaccines
    Zona Pellucida
    New Zealand
    Population
    Fertility
    Alleles
    Peptides

    Cite this

    Holland, Olivia ; Cowan, P ; Gleeson, Dianne ; Duckworth, Janine ; Chamley, Larry. / MHC haplotypes and response to immunocontraceptive vaccines in the brushtail possum. In: Journal of Reproductive Immunology. 2009 ; Vol. 82. pp. 57-65.
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    title = "MHC haplotypes and response to immunocontraceptive vaccines in the brushtail possum",
    abstract = "The possum is a major invasive pest in New Zealand. One option for its control is the use of immunocontraceptive vaccines. Initial trials of vaccines have shown individual variation in response. The use of vaccines on wild populations could result in the evolution of a resistant population through selection for possums that remain fertile because of low or no response. Understanding the basis of this variation is therefore important. The major histocompatibility complex (MHC) is an important influence on the nature of immune responses. This study has investigated the relationship between MHCalleles and individual immune responses to immunocontraceptive vaccines comprising zona pellucida peptides.We identified MHC alleles and putative haplotypes, and compared these between individuals with measured responses to immunocontraceptive vaccines. Two haplotypes were found to associate significantly with differences in vaccine response. Possums that carried haplotype 6 showed reduced responsiveness to one vaccine, while possums that carried haplotype 9 showed increased responsiveness to a separate vaccine. The identification of MHC haplotypes associated with different responses to immunocontraceptive vaccines offers the opportunity to understand what factors trigger non-response and the persistence of fertility in some individuals, and may allow vaccines to be optimised to minimise non-responsiveness.",
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    MHC haplotypes and response to immunocontraceptive vaccines in the brushtail possum. / Holland, Olivia; Cowan, P; Gleeson, Dianne; Duckworth, Janine; Chamley, Larry.

    In: Journal of Reproductive Immunology, Vol. 82, 2009, p. 57-65.

    Research output: Contribution to journalArticle

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    AU - Holland, Olivia

    AU - Cowan, P

    AU - Gleeson, Dianne

    AU - Duckworth, Janine

    AU - Chamley, Larry

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    N2 - The possum is a major invasive pest in New Zealand. One option for its control is the use of immunocontraceptive vaccines. Initial trials of vaccines have shown individual variation in response. The use of vaccines on wild populations could result in the evolution of a resistant population through selection for possums that remain fertile because of low or no response. Understanding the basis of this variation is therefore important. The major histocompatibility complex (MHC) is an important influence on the nature of immune responses. This study has investigated the relationship between MHCalleles and individual immune responses to immunocontraceptive vaccines comprising zona pellucida peptides.We identified MHC alleles and putative haplotypes, and compared these between individuals with measured responses to immunocontraceptive vaccines. Two haplotypes were found to associate significantly with differences in vaccine response. Possums that carried haplotype 6 showed reduced responsiveness to one vaccine, while possums that carried haplotype 9 showed increased responsiveness to a separate vaccine. The identification of MHC haplotypes associated with different responses to immunocontraceptive vaccines offers the opportunity to understand what factors trigger non-response and the persistence of fertility in some individuals, and may allow vaccines to be optimised to minimise non-responsiveness.

    AB - The possum is a major invasive pest in New Zealand. One option for its control is the use of immunocontraceptive vaccines. Initial trials of vaccines have shown individual variation in response. The use of vaccines on wild populations could result in the evolution of a resistant population through selection for possums that remain fertile because of low or no response. Understanding the basis of this variation is therefore important. The major histocompatibility complex (MHC) is an important influence on the nature of immune responses. This study has investigated the relationship between MHCalleles and individual immune responses to immunocontraceptive vaccines comprising zona pellucida peptides.We identified MHC alleles and putative haplotypes, and compared these between individuals with measured responses to immunocontraceptive vaccines. Two haplotypes were found to associate significantly with differences in vaccine response. Possums that carried haplotype 6 showed reduced responsiveness to one vaccine, while possums that carried haplotype 9 showed increased responsiveness to a separate vaccine. The identification of MHC haplotypes associated with different responses to immunocontraceptive vaccines offers the opportunity to understand what factors trigger non-response and the persistence of fertility in some individuals, and may allow vaccines to be optimised to minimise non-responsiveness.

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