@article{68ae55bb64dd4d3fbc8e8acb673c7dc6,
title = "Microbially mediated phenolic catabolites exert differential genoprotective activities in normal and adenocarcinoma cell lines",
abstract = "Age-associated decline of nuclear factor erythroid 2-related factor 2 (Nrf2) activity and DNA repair efficiency leads to the accumulation of DNA damage and increased risk of cancer. Understanding the mechanisms behind increased levels of damaged DNA is crucial for developing interventions to mitigate age-related cancer risk. Associated with various health benefits, (poly)phenols and their microbially mediated phenolic catabolites represent a potential means to reduce DNA damage. Four colonic-microbiota-derived phenolic catabolites were investigated for their ability to reduce H 2O 2-induced oxidative DNA damage and modulate the Nrf2-Antixoidant Response Element (ARE) pathway, in normal (CCD 841 CoN) and adenocarcinoma (HT29) colonocyte cell lines. Each catabolite demonstrated significant ( p < .001) genoprotective activity and modulation of key genes in the Nrf2-ARE pathway. Overall, the colon-derived phenolic metabolites, when assessed at physiologically relevant concentrations, reduced DNA damage in both normal and adenocarcinoma colonic cells in response to oxidative challenge, mediated in part via upregulation of the Nrf2-ARE pathway. ",
keywords = "3-(3′-hydroxyphenyl)propanoic acid, 3-(phenyl)propanoic acid, 4-hydroxybenzoic acid, Benzoic acid, colonic cells, COMET assay",
author = "Murphy, {Brian {\'O}g} and Cheryl Latimer and Sara Dobani and Pourshahidi, {L Kirsty} and Massimilano Fontana and Ternan, {Nigel G} and Gordon McDougall and Ian Rowland and Gema Pereira-Caro and Tuohy, {Kieran M} and {Del Rio}, Daniele and Almutairi, {Tahani M} and Alan Crozier and Nenad Naumovski and Gill, {Chris I R}",
note = "Funding Information: C.I.R.G. and A.C. received funding from the National Processed Raspberry Council who had no involvement in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. G.McD. received funding from the Scottish Government\u2019s Rural and Environment Science and Analytical Services (RESAS) Division. G.McD. received funding from BachBerry (Project No. FP7-613793). G.P.-C. was supported by a postdoctoral research contract \u201CJuan de la Cierva Incorporaci\u00F3n\u201D funded by the Spanish Ministry of Economy and Competitiveness (FJCI-2015-26433). C.I.R.G., A.C., G.P.-C. and T.M.A. were funded by the Distinguished Scientist Fellowship Program (DSFP) of King Saud University, Riyadh, Saudi Arabia. Publisher Copyright: {\textcopyright} 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.",
year = "2024",
doi = "10.1080/09637486.2024.2397055",
language = "English",
volume = "75",
pages = "673--686",
journal = "International Journal of Food Sciences and Nutrition",
issn = "0963-7486",
publisher = "Informa Healthcare",
number = "7",
}
