Modelling and control of the agitation-sedation cycle

Andrew D. Rudge, J. Geoffrey Chase, Geoffrey M. Shaw, Lucy Johnston, Graeme C. Wake

Research output: Contribution to journalConference articlepeer-review

7 Citations (Scopus)


Agitation-sedation cycling in critically ill patients, characterised by oscillations between states of agitation and over-sedation, is damaging to patient health and increases length of stay and healthcare cost. The mathematical model presented captures the essential dynamics of the agitation-sedation system for the first time, and is validated by accurately simulating known patient response. Simulations using heavy derivative control highlight the potential of automated systems to reduce the magnitude, duration, and severity of agitation-sedation cycling, without significant increases in required drug dose.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalIFAC Proceedings Volumes (IFAC-PapersOnline)
Issue number15
Publication statusPublished - 2003
Externally publishedYes
Event5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 - Melbourne, Australia
Duration: 21 Aug 200323 Aug 2003


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