TY - JOUR
T1 - Modelling and control of the agitation-sedation cycle
AU - Rudge, Andrew D.
AU - Chase, J. Geoffrey
AU - Shaw, Geoffrey M.
AU - Johnston, Lucy
AU - Wake, Graeme C.
N1 - Funding Information:
The authors wish to acknowledge Kathryn Greenfield and Richard Dove from the Medical Engineering and Physics Department at Christchurch Hospital, and David Wall from the Department of Mathematics and Statistics at the University of Canterbury for their input to this work. Funding for this research was provided by the New Zealand Foundation for Research, Science and Technology through a Bright Futures Top Achiever Doctoral Scholarship. and by the Todd Foundation through the Award for Excellence.
Publisher Copyright:
Copyright © 2003 IF AC.
PY - 2003
Y1 - 2003
N2 - Agitation-sedation cycling in critically ill patients, characterised by oscillations between states of agitation and over-sedation, is damaging to patient health and increases length of stay and healthcare cost. The mathematical model presented captures the essential dynamics of the agitation-sedation system for the first time, and is validated by accurately simulating known patient response. Simulations using heavy derivative control highlight the potential of automated systems to reduce the magnitude, duration, and severity of agitation-sedation cycling, without significant increases in required drug dose.
AB - Agitation-sedation cycling in critically ill patients, characterised by oscillations between states of agitation and over-sedation, is damaging to patient health and increases length of stay and healthcare cost. The mathematical model presented captures the essential dynamics of the agitation-sedation system for the first time, and is validated by accurately simulating known patient response. Simulations using heavy derivative control highlight the potential of automated systems to reduce the magnitude, duration, and severity of agitation-sedation cycling, without significant increases in required drug dose.
KW - Biomedical control
KW - Non-linear dynamics. dynamic modelling
KW - Pd controllers
KW - Physiological models
UR - http://www.scopus.com/inward/record.url?scp=25144484438&partnerID=8YFLogxK
U2 - 10.1016/S1474-6670(17)33479-1
DO - 10.1016/S1474-6670(17)33479-1
M3 - Conference article
AN - SCOPUS:25144484438
SN - 1474-6670
VL - 36
SP - 89
EP - 94
JO - IFAC Proceedings Volumes (IFAC-PapersOnline)
JF - IFAC Proceedings Volumes (IFAC-PapersOnline)
IS - 15
T2 - 5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003
Y2 - 21 August 2003 through 23 August 2003
ER -