Modelling batch bioreactions with continuous process simulators

Yechun Zhang, Muhammad Tajammal Munir, Wei Yu, Brent Richmond Young

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Process models are increasingly becoming necessary for process understanding and optimizing. However, in the field of bioprocessing, modelling using a generic process simulator suffers from shortcomings given that many simulators cannot model batch mode bioreactors with varying reaction rates based on microbial metabolism. Bioprocesses, mostly batch, are difficult to model because most of the available unit operations in process simulators operate continuously. Our aim is to provide a general simulation platform to model these batch bioprocesses in commercial process simulators and explain how to transform batch processes with varying reaction rate into continuous unit operations for simulation purposes. Two typical fermentation processes, lactose fermentation and glucose/xylose co-fermentation, were simulated in steady state as case studies. The results are discussed as examples using the proposed approach. The potential of how to extend the simulation platform is also explained in detail.

Original languageEnglish
Pages (from-to)3343-3349
Number of pages7
JournalKorean Journal of Chemical Engineering
Issue number12
Publication statusPublished - 1 Dec 2016
Externally publishedYes


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