The purpose of this study was to assess the effects of two different exercise doses on cardiometabolic risk factors in overweight children. Participants were randomly assigned to either moderate-intensity high-frequency exercise or vigorous-intensity low-frequency exercise for a total duration of 6 weeks. The moderate-intensity high-frequency group (n = 5) participated in 30 sessions, which were set at 40%-60% of heart rate reserve. The vigorous-intensity low-frequency group (n = 7) participated in 18 sessions, which were set at 60%-80% heart rate reserve. The results showed that fasting glucose level (-6.79%, p < 0.13) responded better to moderate-intensity high-frequency exercise whereas vigorous-intensity low-frequency exercise induced greater improvements in systolic blood pressure (-5.98%, p < 0.23) with a mean change of-6.4 mmHg. This study showed that two different exercise doses improved selected cardiometabolic variables in overweight children. Hence, this study provides exercise recommendations for achieving specific cardiometabolic health benefits in overweight children.