Modulation of a surface antigen of Entamoeba histolytica in response to bacteria

A Bhattacharya, R Ghildyal, J Prasad, S Bhattacharya, L S Diamond

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Changes in the cell surface of Entamoeba histolytica, a human intestinal parasite and the causative agent of amebic dysentery, were examined with a monoclonal antibody, 2D7.10, which selectively recognizes carbohydrate epitopes in some axenic amebic strains. While high-level expression of this epitope was observed in axenic amebae, it was either absent or present only in small amounts in xenic amebae. Furthermore, reassociation of the axenic amebae with intestinal flora resulted in loss of the 2D7.10 epitope. Our data suggest that surface antigens of E. histolytica can be modulated in response to bacteria and may provide an explanation for the observed influence of bacteria on amebic virulence.

Original languageEnglish
Pages (from-to)1711-1713
Number of pages3
JournalInfection and Immunity
Volume60
Issue number4
Publication statusPublished - Apr 1992
Externally publishedYes

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