@article{7cc5f121afe2403a80f829f29e556e6d,
title = "Molecular epidemiology and glycomics of swine influenza viruses circulating in commercial swine farms in the southeastern and midwest United States",
abstract = "Tracking the genetic diversity and spread of swine influenza viruses (SIVs) in commercial swine farms is central for control and to reduce the potential emergence of SIV reassortants. We analyzed the diversity of SIVs in nasal washes or oral fluids from commercial swine farms in North Carolina using influenza M qRT-PCR and hemagglutinin (HA) and neuraminidase (NA) subtyping. We found a predominance of H1 HAs and N2 NAs in the samples examined. The majority of the H1 HAs could be further classified into gamma and delta subclusters. We also identified HAs of the H1 alpha cluster, and those of human novel pandemic origin. Glycan binding profiles from a representative subset of these viruses revealed broad α2,6 sialylated glycan recognition, though some strains exhibited the ability to bind to α2,3 sialic acid. These data show that SIV surveillance can aid our understanding of viral transmission dynamics and help uncover the diversity at the human-swine interface.",
keywords = "Hemagglutinin, Neuraminidase, Phylogenetics, Surveillance, Swine influenza virus",
author = "Bakre, {Abhijeet A.} and Jones, {Les P.} and Kyriakis, {Constantinos S.} and Hanson, {Jarod M.} and Bobbitt, {Davis E.} and Bennett, {Hailey K.} and Todd, {Kyle V.} and Nichole Orr-Burks and Jackelyn Murray and Ming Zhang and Steinhauer, {David A.} and Lauren Byrd-Leotis and Cummings, {Richard D.} and Joseph Fent and Terry Coffey and Tripp, {Ralph A.}",
note = "Funding Information: This work was funded by the NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS) , contract number HHSN272201400004C and HHSN266200700006C to RAT. Sequences described in this manuscript have been submitted to the NIH data processing and coordinating Center (DPCC) for submission to GenBank. Accession numbers will be posted as they become available. Funding Information: This work was funded by the NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS), contract number HHSN272201400004C and HHSN266200700006C to RAT. Sequences described in this manuscript have been submitted to the NIH data processing and coordinating Center (DPCC) for submission to GenBank. Accession numbers will be posted as they become available. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
month = dec,
doi = "10.1016/j.vetmic.2020.108914",
language = "English",
volume = "251",
pages = "1--8",
journal = "Veterinary Microbiology",
issn = "0378-1135",
publisher = "Elsevier",
}