TY - JOUR
T1 - Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients
T2 - A New Perspective in Rehabilitation
AU - Botek, Michal
AU - Krejčí, Jakub
AU - Valenta, Michal
AU - McKune, Andrew
AU - Sládečková, Barbora
AU - Konečný, Petr
AU - Klimešová, Iva
AU - Pastucha, Dalibor
N1 - Funding Information:
Funding: This research was funded by Palacký University Olomouc, Olomouc, Czech Republic, grant number IGA_FTK_2021_009. This research was also supported by the research project of science and technology park BALUO Application Centre of Faculty of Physical Culture, Palacký University Olomouc, Olomouc, Czech Republic, entitled: “Assessment of the effectiveness of healthy and active lifestyle of adult individuals on selected health indicators with the participants of research conducted by BALUO Application Centre of Faculty of Physical Culture, Palacký University Olomouc–retrospective study”. The APC was funded by Palacký University Olomouc, Olomouc, Czech Republic.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This random-ized, single-blind, placebo-controlled study included 26 males (44 ± 17 years) and 24 females (38 ± 12 years), who performed a 6-min walking test (6 MWT) and pulmonary function test, specifically forced vital capacity (FVC) and expiratory volume in the first second (FEV1). Symptomatic participants were recruited between 21 and 33 days after a positive polymerase chain reaction test. The experiment consisted of H2/placebo inhalation, 2 × 60 min/day for 14 days. Results showed that H2 therapy, compared with placebo, significantly increased 6 MWT distance by 64 ± 39 m, FVC by 0.19 ± 0.24 L, and, in FEV1, by 0.11 ± 0.28 L (all p ≤ 0.025). In conclusion, H2 inhalation had beneficial health effects in terms of improved physical and respiratory function in acute post-COVID-19 pa-tients. Therefore, H2 inhalation may represent a safe, effective approach for accelerating early function restoration in post-COVID-19 patients.
AB - Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This random-ized, single-blind, placebo-controlled study included 26 males (44 ± 17 years) and 24 females (38 ± 12 years), who performed a 6-min walking test (6 MWT) and pulmonary function test, specifically forced vital capacity (FVC) and expiratory volume in the first second (FEV1). Symptomatic participants were recruited between 21 and 33 days after a positive polymerase chain reaction test. The experiment consisted of H2/placebo inhalation, 2 × 60 min/day for 14 days. Results showed that H2 therapy, compared with placebo, significantly increased 6 MWT distance by 64 ± 39 m, FVC by 0.19 ± 0.24 L, and, in FEV1, by 0.11 ± 0.28 L (all p ≤ 0.025). In conclusion, H2 inhalation had beneficial health effects in terms of improved physical and respiratory function in acute post-COVID-19 pa-tients. Therefore, H2 inhalation may represent a safe, effective approach for accelerating early function restoration in post-COVID-19 patients.
KW - 6-min walking test
KW - COVID-19
KW - Fatigue
KW - Health
KW - Hydrogen inhalation
KW - Oxygen saturation
KW - Pulmonary function
UR - http://www.scopus.com/inward/record.url?scp=85124209433&partnerID=8YFLogxK
U2 - 10.3390/ijerph19041992
DO - 10.3390/ijerph19041992
M3 - Article
AN - SCOPUS:85124209433
SN - 1661-7827
VL - 19
SP - 1
EP - 14
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 4
M1 - 1992
ER -
