Motor adaptation varies between individuals in the transition to sustained pain

Simon J Summers, Lucy S Chipchase, Rogerio Hirata, Thomas Graven-Nielsen, Rocco Cavaleri, Siobhan M Schabrun

Research output: Contribution to journalArticle

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Abstract

Musculoskeletal pain is associated with altered motor control that, despite short-term benefit, is hypothesised to have long-term consequences, contributing to the development of chronic pain. However, data on how motor control is alteredwhen pain is sustained beyond a transient event are scarce. Here, we investigated motor adaptation, and its relationship with corticomotor excitability, in the transition to sustainedmuscle pain. Twenty-eight healthy individuals were injected with nerve growth factor into the right extensor carpi radialis brevis muscle on days 0 and 2. Motor adaptation and corticomotor excitability were assessed on day 22, before injection on days 0 and 2, and again on days 4 and 14.Motor adaptation was quantified during a radial-ulnarmovement as kinematic variability of wrist flexion-extension and pronation-supination, and as electromyographic (EMG) variability of extensor carpi radialis brevis activity. Pain,muscle soreness, and functional limitationwere assessed fromdays 0 to 14. Pain, muscle soreness, and functional limitation were evident at days 2 and 4 (P < 0.001). Electromyographic variability reduced at days 4 and 14 (P < 0.04), with no change in kinematic variability (P = 0.9). However, data revealed variation in EMG and kinematic variability between individuals: some displayed increased motor variability,whereas others a decrease. Individualswho displayed an increase in EMGvariability after 4 days of pain also displayed an increase in corticomotor excitability (r = 0.43, P = 0.034). These findings suggest individual adaptation of the motor system in the transition to sustained pain that could have implications for clinical musculoskeletal pain disorders.

Original languageEnglish
Pages (from-to)2115-2125
Number of pages11
JournalPain
Volume160
Issue number9
Early online date8 May 2019
DOIs
Publication statusPublished - 2019

Fingerprint

Pain
Biomechanical Phenomena
Musculoskeletal Pain
Myalgia
Pronation
Supination
Somatoform Disorders
Nerve Growth Factor
Wrist
Chronic Pain
Muscles
Injections

Cite this

Summers, S. J., Chipchase, L. S., Hirata, R., Graven-Nielsen, T., Cavaleri, R., & Schabrun, S. M. (2019). Motor adaptation varies between individuals in the transition to sustained pain. Pain, 160(9), 2115-2125. https://doi.org/10.1097/j.pain.0000000000001604
Summers, Simon J ; Chipchase, Lucy S ; Hirata, Rogerio ; Graven-Nielsen, Thomas ; Cavaleri, Rocco ; Schabrun, Siobhan M. / Motor adaptation varies between individuals in the transition to sustained pain. In: Pain. 2019 ; Vol. 160, No. 9. pp. 2115-2125.
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Summers, SJ, Chipchase, LS, Hirata, R, Graven-Nielsen, T, Cavaleri, R & Schabrun, SM 2019, 'Motor adaptation varies between individuals in the transition to sustained pain', Pain, vol. 160, no. 9, pp. 2115-2125. https://doi.org/10.1097/j.pain.0000000000001604

Motor adaptation varies between individuals in the transition to sustained pain. / Summers, Simon J; Chipchase, Lucy S; Hirata, Rogerio; Graven-Nielsen, Thomas; Cavaleri, Rocco; Schabrun, Siobhan M.

In: Pain, Vol. 160, No. 9, 2019, p. 2115-2125.

Research output: Contribution to journalArticle

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AU - Summers, Simon J

AU - Chipchase, Lucy S

AU - Hirata, Rogerio

AU - Graven-Nielsen, Thomas

AU - Cavaleri, Rocco

AU - Schabrun, Siobhan M

PY - 2019

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Summers SJ, Chipchase LS, Hirata R, Graven-Nielsen T, Cavaleri R, Schabrun SM. Motor adaptation varies between individuals in the transition to sustained pain. Pain. 2019;160(9):2115-2125. https://doi.org/10.1097/j.pain.0000000000001604