Abstract
Mx proteins are interferon-induced members of the dynamin superfamily of large guanosine triphosphatases. These proteins have attracted attention because some display antiviral activity against pathogenic RNA viruses, for example against members of the orthomyxovirus (influenzavirus) family or the bunyavirus family. Transfected cells and transgenic mice expressing Mx proteins are highly resistant to Mx-sensitive viruses, demonstrating that Mx proteins are powerful antiviral agents. In humans, synthesis of MxA is observed during self-limiting viral infections and may thus promote recovery from disease.
| Original language | English |
|---|---|
| Pages (from-to) | 220-230 |
| Number of pages | 11 |
| Journal | OIE Revue Scientifique et Technique |
| Volume | 17 |
| Issue number | 1 |
| Publication status | Published - 1 Dec 1998 |
| Externally published | Yes |
Fingerprint
Cite this
Haller, O., Frese, M., & Kochs, G. (1998). Mx proteins: Mediators of innate resistance to RNA viruses. OIE Revue Scientifique et Technique, 17(1), 220-230.