Abstract
Mx proteins are interferon-induced members of the dynamin superfamily of large guanosine triphosphatases. These proteins have attracted attention because some display antiviral activity against pathogenic RNA viruses, for example against members of the orthomyxovirus (influenzavirus) family or the bunyavirus family. Transfected cells and transgenic mice expressing Mx proteins are highly resistant to Mx-sensitive viruses, demonstrating that Mx proteins are powerful antiviral agents. In humans, synthesis of MxA is observed during self-limiting viral infections and may thus promote recovery from disease.
| Original language | English |
|---|---|
| Pages (from-to) | 220-230 |
| Number of pages | 11 |
| Journal | OIE Revue Scientifique et Technique |
| Volume | 17 |
| Issue number | 1 |
| Publication status | Published - 1 Dec 1998 |
| Externally published | Yes |
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Mx proteins: Mediators of innate resistance to RNA viruses. / Haller, O.; Frese, M.; Kochs, G.
In: OIE Revue Scientifique et Technique, Vol. 17, No. 1, 01.12.1998, p. 220-230.Research output: Contribution to journal › Article
TY - JOUR
T1 - Mx proteins: Mediators of innate resistance to RNA viruses
AU - Haller, O.
AU - Frese, M.
AU - Kochs, G.
PY - 1998/12/1
Y1 - 1998/12/1
N2 - Mx proteins are interferon-induced members of the dynamin superfamily of large guanosine triphosphatases. These proteins have attracted attention because some display antiviral activity against pathogenic RNA viruses, for example against members of the orthomyxovirus (influenzavirus) family or the bunyavirus family. Transfected cells and transgenic mice expressing Mx proteins are highly resistant to Mx-sensitive viruses, demonstrating that Mx proteins are powerful antiviral agents. In humans, synthesis of MxA is observed during self-limiting viral infections and may thus promote recovery from disease.
AB - Mx proteins are interferon-induced members of the dynamin superfamily of large guanosine triphosphatases. These proteins have attracted attention because some display antiviral activity against pathogenic RNA viruses, for example against members of the orthomyxovirus (influenzavirus) family or the bunyavirus family. Transfected cells and transgenic mice expressing Mx proteins are highly resistant to Mx-sensitive viruses, demonstrating that Mx proteins are powerful antiviral agents. In humans, synthesis of MxA is observed during self-limiting viral infections and may thus promote recovery from disease.
KW - Antiviral agents
KW - Disease resistance
KW - Genetics
KW - Guanosine triphosphatase
KW - Influenzavirus
KW - Interferons
KW - Mx protein
KW - Transgenic animals
UR - http://www.scopus.com/inward/record.url?scp=0032036611&partnerID=8YFLogxK
UR - http://doc.oie.int:8080/dyn/portal/index.seam?page=alo&aloId=29119
M3 - Article
VL - 17
SP - 220
EP - 230
JO - Scientific and Technical Review
JF - Scientific and Technical Review
SN - 0253-1933
IS - 1
ER -