Mx proteins: Mediators of innate resistance to RNA viruses

O. Haller, M. Frese, G. Kochs

Research output: Contribution to journalArticle

239 Citations (Scopus)

Abstract

Mx proteins are interferon-induced members of the dynamin superfamily of large guanosine triphosphatases. These proteins have attracted attention because some display antiviral activity against pathogenic RNA viruses, for example against members of the orthomyxovirus (influenzavirus) family or the bunyavirus family. Transfected cells and transgenic mice expressing Mx proteins are highly resistant to Mx-sensitive viruses, demonstrating that Mx proteins are powerful antiviral agents. In humans, synthesis of MxA is observed during self-limiting viral infections and may thus promote recovery from disease.

Original languageEnglish
Pages (from-to)220-230
Number of pages11
JournalOIE Revue Scientifique et Technique
Volume17
Issue number1
Publication statusPublished - 1 Dec 1998
Externally publishedYes

Fingerprint

Myxovirus Resistance Proteins
RNA Viruses
Antiviral Agents
Orthobunyavirus
Dynamins
Guanosine
Virus Diseases
Orthomyxoviridae
Transgenic Mice
proteins
antiviral agents
Viruses
guanosinetriphosphatase
interferons
Proteins
genetically modified organisms
viruses
synthesis
RNA viruses
mice

Cite this

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Mx proteins: Mediators of innate resistance to RNA viruses. / Haller, O.; Frese, M.; Kochs, G.

In: OIE Revue Scientifique et Technique, Vol. 17, No. 1, 01.12.1998, p. 220-230.

Research output: Contribution to journalArticle

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AU - Frese, M.

AU - Kochs, G.

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KW - Genetics

KW - Guanosine triphosphatase

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