Neonatal Hypoglycaemia and Visual Development

A Review

Nabin Paudel, Arijit Chakraborty, Nicola Anstice, Robert J. Jacobs, Jo E. Hegarty, Jane E. Harding, Benjamin Thompson

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Background: Many newborn babies experience low blood glucose concentrations, a condition referred to as neonatal hypoglycaemia (NH). The effect of NH on visual development in infancy and childhood is of interest because the occipital lobes, which include the primary visual cortex and a number of extrastriate visual areas, may be particularly susceptible to NH-induced injury. In addition, a number of case series have suggested that NH can affect eye and optic nerve development. Objective: To review the existing literature concerning the effect of NH on the visual system. Methods: A PubMed, Embase, Medline, and Google Scholar literature search was conducted using prespecified MeSH terms. Results: The literature reviewed revealed no clear evidence for an effect of NH on the development of the eye and optic nerve. Furthermore, occipital and occipital-parietal lobe injuries following NH often occurred in conjunction with comorbid conditions and were not clearly linked to subsequent visual dysfunction, possibly due to difficulties in measuring vision in young children and a lack of studies at older ages. A recent, large-scale, prospective study of NH outcomes at 2 years of age found no effect of mild-to-moderate NH on visual development. Conclusion: The effect of NH on visual development is unclear. It is currently unknown whether NH affects visual function in mid-to-late childhood when many visual functions reach adult levels.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalNeonatology
Volume112
Issue number1
DOIs
Publication statusPublished - 1 Jun 2017
Externally publishedYes

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Hypoglycemia
Occipital Lobe
Optic Nerve
Parietal Lobe
Wounds and Injuries
Visual Cortex
PubMed
Blood Glucose
Newborn Infant
Prospective Studies

Cite this

Paudel, N., Chakraborty, A., Anstice, N., Jacobs, R. J., Hegarty, J. E., Harding, J. E., & Thompson, B. (2017). Neonatal Hypoglycaemia and Visual Development: A Review. Neonatology, 112(1), 47-52. https://doi.org/10.1159/000456705
Paudel, Nabin ; Chakraborty, Arijit ; Anstice, Nicola ; Jacobs, Robert J. ; Hegarty, Jo E. ; Harding, Jane E. ; Thompson, Benjamin. / Neonatal Hypoglycaemia and Visual Development : A Review. In: Neonatology. 2017 ; Vol. 112, No. 1. pp. 47-52.
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abstract = "Background: Many newborn babies experience low blood glucose concentrations, a condition referred to as neonatal hypoglycaemia (NH). The effect of NH on visual development in infancy and childhood is of interest because the occipital lobes, which include the primary visual cortex and a number of extrastriate visual areas, may be particularly susceptible to NH-induced injury. In addition, a number of case series have suggested that NH can affect eye and optic nerve development. Objective: To review the existing literature concerning the effect of NH on the visual system. Methods: A PubMed, Embase, Medline, and Google Scholar literature search was conducted using prespecified MeSH terms. Results: The literature reviewed revealed no clear evidence for an effect of NH on the development of the eye and optic nerve. Furthermore, occipital and occipital-parietal lobe injuries following NH often occurred in conjunction with comorbid conditions and were not clearly linked to subsequent visual dysfunction, possibly due to difficulties in measuring vision in young children and a lack of studies at older ages. A recent, large-scale, prospective study of NH outcomes at 2 years of age found no effect of mild-to-moderate NH on visual development. Conclusion: The effect of NH on visual development is unclear. It is currently unknown whether NH affects visual function in mid-to-late childhood when many visual functions reach adult levels.",
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Paudel, N, Chakraborty, A, Anstice, N, Jacobs, RJ, Hegarty, JE, Harding, JE & Thompson, B 2017, 'Neonatal Hypoglycaemia and Visual Development: A Review', Neonatology, vol. 112, no. 1, pp. 47-52. https://doi.org/10.1159/000456705

Neonatal Hypoglycaemia and Visual Development : A Review. / Paudel, Nabin; Chakraborty, Arijit; Anstice, Nicola; Jacobs, Robert J.; Hegarty, Jo E.; Harding, Jane E.; Thompson, Benjamin.

In: Neonatology, Vol. 112, No. 1, 01.06.2017, p. 47-52.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Neonatal Hypoglycaemia and Visual Development

T2 - A Review

AU - Paudel, Nabin

AU - Chakraborty, Arijit

AU - Anstice, Nicola

AU - Jacobs, Robert J.

AU - Hegarty, Jo E.

AU - Harding, Jane E.

AU - Thompson, Benjamin

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Many newborn babies experience low blood glucose concentrations, a condition referred to as neonatal hypoglycaemia (NH). The effect of NH on visual development in infancy and childhood is of interest because the occipital lobes, which include the primary visual cortex and a number of extrastriate visual areas, may be particularly susceptible to NH-induced injury. In addition, a number of case series have suggested that NH can affect eye and optic nerve development. Objective: To review the existing literature concerning the effect of NH on the visual system. Methods: A PubMed, Embase, Medline, and Google Scholar literature search was conducted using prespecified MeSH terms. Results: The literature reviewed revealed no clear evidence for an effect of NH on the development of the eye and optic nerve. Furthermore, occipital and occipital-parietal lobe injuries following NH often occurred in conjunction with comorbid conditions and were not clearly linked to subsequent visual dysfunction, possibly due to difficulties in measuring vision in young children and a lack of studies at older ages. A recent, large-scale, prospective study of NH outcomes at 2 years of age found no effect of mild-to-moderate NH on visual development. Conclusion: The effect of NH on visual development is unclear. It is currently unknown whether NH affects visual function in mid-to-late childhood when many visual functions reach adult levels.

AB - Background: Many newborn babies experience low blood glucose concentrations, a condition referred to as neonatal hypoglycaemia (NH). The effect of NH on visual development in infancy and childhood is of interest because the occipital lobes, which include the primary visual cortex and a number of extrastriate visual areas, may be particularly susceptible to NH-induced injury. In addition, a number of case series have suggested that NH can affect eye and optic nerve development. Objective: To review the existing literature concerning the effect of NH on the visual system. Methods: A PubMed, Embase, Medline, and Google Scholar literature search was conducted using prespecified MeSH terms. Results: The literature reviewed revealed no clear evidence for an effect of NH on the development of the eye and optic nerve. Furthermore, occipital and occipital-parietal lobe injuries following NH often occurred in conjunction with comorbid conditions and were not clearly linked to subsequent visual dysfunction, possibly due to difficulties in measuring vision in young children and a lack of studies at older ages. A recent, large-scale, prospective study of NH outcomes at 2 years of age found no effect of mild-to-moderate NH on visual development. Conclusion: The effect of NH on visual development is unclear. It is currently unknown whether NH affects visual function in mid-to-late childhood when many visual functions reach adult levels.

KW - Brain injury

KW - Neonatal hypoglycaemia

KW - Neurodevelopment

KW - Occipital cortex

KW - Vision

KW - Visual function

KW - Visual processing

U2 - 10.1159/000456705

DO - 10.1159/000456705

M3 - Review article

VL - 112

SP - 47

EP - 52

JO - Neonatology

JF - Neonatology

SN - 0006-3126

IS - 1

ER -

Paudel N, Chakraborty A, Anstice N, Jacobs RJ, Hegarty JE, Harding JE et al. Neonatal Hypoglycaemia and Visual Development: A Review. Neonatology. 2017 Jun 1;112(1):47-52. https://doi.org/10.1159/000456705