Neuronal and glial γ-aminobutyric acid+ transporters are distinct proteins

Nicola J. Mabjeesh, Michael Frese, Thomas Rauen, Gunnar Jeserich, Baruch I. Kanner

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to β-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to β-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalFEBS Letters
Volume299
Issue number1
DOIs
Publication statusPublished - 2 Mar 1992
Externally publishedYes

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Aminobutyrates
Sodium Chloride
Neuroglia
Alanine
GABA Plasma Membrane Transport Proteins
Neurology
Immunoblotting
gamma-Aminobutyric Acid
Epitopes
Proteins
Central Nervous System
Membranes
Antibodies

Cite this

Mabjeesh, Nicola J. ; Frese, Michael ; Rauen, Thomas ; Jeserich, Gunnar ; Kanner, Baruch I. / Neuronal and glial γ-aminobutyric acid+ transporters are distinct proteins. In: FEBS Letters. 1992 ; Vol. 299, No. 1. pp. 99-102.
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Neuronal and glial γ-aminobutyric acid+ transporters are distinct proteins. / Mabjeesh, Nicola J.; Frese, Michael; Rauen, Thomas; Jeserich, Gunnar; Kanner, Baruch I.

In: FEBS Letters, Vol. 299, No. 1, 02.03.1992, p. 99-102.

Research output: Contribution to journalArticle

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