Neuronal and glial γ-aminobutyric acid+ transporters are distinct proteins

Nicola J. Mabjeesh, Michael Frese, Thomas Rauen, Gunnar Jeserich, Baruch I. Kanner

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to β-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to β-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalFEBS Letters
Volume299
Issue number1
DOIs
Publication statusPublished - 2 Mar 1992
Externally publishedYes

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