Neuronal and glial γ-aminobutyric acid+ transporters are distinct proteins

Nicola J. Mabjeesh; Michael Frese; Thomas Rauen; Gunnar Jeserich; Baruch I. Kanner

doi:10.1016/0014-5793(92)80109-T

Neuronal and glial γ-aminobutyric acid⁺ transporters are distinct proteins

Nicola J. Mabjeesh, Michael Frese, Thomas Rauen, Gunnar Jeserich, Baruch I. Kanner

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to β-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to β-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.

Original language	English
Pages (from-to)	99-102
Number of pages	4
Journal	FEBS Letters
Volume	299
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(92)80109-T
Publication status	Published - 2 Mar 1992
Externally published	Yes

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title = "Neuronal and glial γ-aminobutyric acid+ transporters are distinct proteins",

abstract = "In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to β-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to β-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.",

keywords = "Astroglial cell, GABA transport, Immunoblotting, Immunofluorescence, Membrane vesicle, Sequence directed antibody",

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T1 - Neuronal and glial γ-aminobutyric acid+ transporters are distinct proteins

AU - Mabjeesh, Nicola J.

AU - Frese, Michael

AU - Rauen, Thomas

AU - Jeserich, Gunnar

AU - Kanner, Baruch I.

PY - 1992/3/2

Y1 - 1992/3/2

N2 - In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to β-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to β-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.

AB - In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to β-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to β-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.

KW - Astroglial cell

KW - GABA transport

KW - Immunoblotting

KW - Immunofluorescence

KW - Membrane vesicle

KW - Sequence directed antibody

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AN - SCOPUS:0026573913

SN - 0014-5793

VL - 299

SP - 99

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JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

Neuronal and glial γ-aminobutyric acid⁺ transporters are distinct proteins

Abstract

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