No effect of a whey growth factor extract during resistance training on strength, body composition, or hypertrophic gene expression in resistance-trained young men

Michael John Dale, Alison M. Coates, Peter R.C. Howe, Grant R. Tomkinson, Matthew T. Haren, Andrew Brown, Marissa Caldow, David Cameron-Smith, Jonathan D. Buckley

Research output: Contribution to journalArticle

Abstract

Growth factors can be isolated from bovine milk to form a whey growth factor extract (WGFE). This study examined whether WGFE promoted activation of the AKT/mTOR pathway enabling increased lean tissue mass and strength in resistance trained men. Forty six men with >6 months of resistance training (RT) experience performed 12 weeks of RT. Participants consumed 20 g/day of whey protein and were randomised to receive either 1.6 g WGFE/day (WGFE; n = 22) or 1.6 g cellulose/day (control, CONT; n = 24). The primary outcome was leg press one-repetition maximum (LP1-RM) which was assessed at baseline, 6 and 12 weeks. At baseline and 12 weeks body composition was assessed by dual energy x-ray absorptiometry, and muscle protein synthesis and gene expression were assessed (vastus lateralis biopsy) in a sub-sample (WGFE n = 10, CONT n = 10) pre- and 3 hr post-training. RT increased LP1-RM (+34.9%) and lean tissue mass (+2.3%; p < 0.05) with no difference between treatments (p > 0.48, treatment x time). Post-exercise P70s6k phosphorylation increased acutely, FOXO3a phosphorylation was unaltered. There were no differences in kinase signalling or gene expression between treatments. Compared with CONT, WGFE did not result in greater increases in lean tissue mass or strength in experienced resistance trained men.

Original languageEnglish
Pages (from-to)230-238
Number of pages9
JournalJournal of Sports Science and Medicine
Volume16
Issue number2
Publication statusPublished - Jun 2017
Externally publishedYes

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Resistance Training
Body Composition
Intercellular Signaling Peptides and Proteins
Gene Expression
Phosphorylation
70-kDa Ribosomal Protein S6 Kinases
Muscle Proteins
Quadriceps Muscle
Whey
Cellulose
Leg
Milk
Phosphotransferases
X-Rays
Exercise
Biopsy
Therapeutics

Cite this

Dale, Michael John ; Coates, Alison M. ; Howe, Peter R.C. ; Tomkinson, Grant R. ; Haren, Matthew T. ; Brown, Andrew ; Caldow, Marissa ; Cameron-Smith, David ; Buckley, Jonathan D. / No effect of a whey growth factor extract during resistance training on strength, body composition, or hypertrophic gene expression in resistance-trained young men. In: Journal of Sports Science and Medicine. 2017 ; Vol. 16, No. 2. pp. 230-238.
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Dale, MJ, Coates, AM, Howe, PRC, Tomkinson, GR, Haren, MT, Brown, A, Caldow, M, Cameron-Smith, D & Buckley, JD 2017, 'No effect of a whey growth factor extract during resistance training on strength, body composition, or hypertrophic gene expression in resistance-trained young men', Journal of Sports Science and Medicine, vol. 16, no. 2, pp. 230-238.

No effect of a whey growth factor extract during resistance training on strength, body composition, or hypertrophic gene expression in resistance-trained young men. / Dale, Michael John; Coates, Alison M.; Howe, Peter R.C.; Tomkinson, Grant R.; Haren, Matthew T.; Brown, Andrew; Caldow, Marissa; Cameron-Smith, David; Buckley, Jonathan D.

In: Journal of Sports Science and Medicine, Vol. 16, No. 2, 06.2017, p. 230-238.

Research output: Contribution to journalArticle

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AU - Coates, Alison M.

AU - Howe, Peter R.C.

AU - Tomkinson, Grant R.

AU - Haren, Matthew T.

AU - Brown, Andrew

AU - Caldow, Marissa

AU - Cameron-Smith, David

AU - Buckley, Jonathan D.

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