Non-coding RNA in Spermatogenesis and Epididymal Maturation

J. E. Holt, S. J. Stanger, B. Nixon, E. A. McLaughlin

Research output: A Conference proceeding or a Chapter in BookChapterpeer-review

29 Citations (Scopus)


Testicular germ and somatic cells express many classes of small ncRNAs, including Dicer-independent PIWI-interacting RNAs, Dicer-dependent miRNAs, and endogenous small interfering RNA. Several studies have identified ncRNAs that are highly, exclusively, or preferentially expressed in the testis and epididymis in specific germ and somatic cell types. Temporal and spatial expression of proteins is a key requirement of successful spermatogenesis and large-scale gene transcription occurs in two key stages, just prior to transcriptional quiescence in meiosis and then during spermiogenesis just prior to nuclear silencing in elongating spermatids. More than 60 % of these transcripts are then stockpiled for subsequent translation. In this capacity ncRNAs may act to interpret and transduce cellular signals to either maintain the undifferentiated stem cell population and/or drive cell differentiation during spermatogenesis and epididymal maturation. The assignation of specific roles to the majority of ncRNA species implicated as having a role in spermatogenesis and epididymal function will underpin fundamental understanding of normal and disease states in humans such as infertility and the development of germ cell tumours.

Original languageEnglish
Title of host publicationNon-coding RNA and the Reproductive System
EditorsDagmar Wilhelm, Pascal Bernard
Place of PublicationDordrecht Netherlands
Number of pages26
ISBN (Electronic) 9789401774178
ISBN (Print) 9789401774154
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


Dive into the research topics of 'Non-coding RNA in Spermatogenesis and Epididymal Maturation'. Together they form a unique fingerprint.

Cite this