Novel Insights into Hepatitis C Virus Replication and Persistence

Ralf Bartenschlager, Michael Frese, Thomas Pietschmann

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) is a small enveloped RNA virus that belongs to the family Flaviviridae. A hallmark of HCV is its high propensity to establish a persistent infection that in many cases leads to chronic liver disease. Molecular studies of the virus became possible with the first successful cloning of its genome in 1989. Since then, the genomic organization has been delineated, and viral proteins have been studied in some detail. In 1999, an efficient cell culture system became available that recapitulates the intracellular part of the HCV life cycle, thereby allowing detailed molecular studies of various aspects of viral RNA replication and persistence. This chapter attempts to summarize the current state of knowledge in these most actively worked on fields of HCV research
Original languageEnglish
Pages (from-to)71-180
Number of pages110
JournalAdvances in Virus Research
Volume63
DOIs
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Virus Replication
Hepacivirus
Flaviviridae
RNA Viruses
Viral RNA
Viral Proteins
Life Cycle Stages
Liver Diseases
Organism Cloning
Chronic Disease
Cell Culture Techniques
Genome
Viruses
Infection
Research

Cite this

Bartenschlager, Ralf ; Frese, Michael ; Pietschmann, Thomas. / Novel Insights into Hepatitis C Virus Replication and Persistence. In: Advances in Virus Research. 2004 ; Vol. 63. pp. 71-180.
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Novel Insights into Hepatitis C Virus Replication and Persistence. / Bartenschlager, Ralf; Frese, Michael; Pietschmann, Thomas.

In: Advances in Virus Research, Vol. 63, 2004, p. 71-180.

Research output: Contribution to journalArticle

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