NTproBNP concentrations in healthy children

Gus Koerbin, W Abhayaratna, Julia Potter, S Apostoloska, Richard Telford, Peter Hickman

Research output: Contribution to journalArticle

Abstract

Introduction
There have been limited studies generating BNP and NT-proBNP reference intervals for paediatric populations. We prospectively assessed NT-proBNP levels in a cohort of 854 healthy school children from the Lifestyle of Our Kids (LOOK) prospective longitudinal study.

Materials and methods
NT-proBNP analysis was performed on 172 girls and 212 boys with average age 8.1 years, 183 girls and 181 boys, average age 10.1 years and 183 girls and 180 boys with average age 11.9 years. Data were stratified according to age and gender with the median, range of results and 2.5th and 97.5th percentiles calculated

Results
There were no significant differences between males and females at any of the 3 study ages. Significant differences were seen between the 8 and 12 year-olds, 10 and 12 year-olds and the 8 and 12 year-old boys.

Discussion
Our study demonstrated that NT-proBNP concentrations in healthy children progressively decline between ages 8 and 12 years. Our selection of unambiguously healthy children produced similar median but lower 97.5th percentile NT-proBNP concentrations to previously published studies
Original languageEnglish
Pages (from-to)1158-1160
Number of pages3
JournalClinical Biochemistry
Volume45
Issue number15
DOIs
Publication statusPublished - 2012

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Pediatrics
Longitudinal Studies
Life Style
Prospective Studies
pro-brain natriuretic peptide (1-76)
Population

Cite this

Koerbin, G., Abhayaratna, W., Potter, J., Apostoloska, S., Telford, R., & Hickman, P. (2012). NTproBNP concentrations in healthy children. Clinical Biochemistry, 45(15), 1158-1160. https://doi.org/10.1016/J.CLINBIOCHEM.2012.05.008
Koerbin, Gus ; Abhayaratna, W ; Potter, Julia ; Apostoloska, S ; Telford, Richard ; Hickman, Peter. / NTproBNP concentrations in healthy children. In: Clinical Biochemistry. 2012 ; Vol. 45, No. 15. pp. 1158-1160.
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Koerbin, G, Abhayaratna, W, Potter, J, Apostoloska, S, Telford, R & Hickman, P 2012, 'NTproBNP concentrations in healthy children', Clinical Biochemistry, vol. 45, no. 15, pp. 1158-1160. https://doi.org/10.1016/J.CLINBIOCHEM.2012.05.008

NTproBNP concentrations in healthy children. / Koerbin, Gus; Abhayaratna, W; Potter, Julia; Apostoloska, S; Telford, Richard; Hickman, Peter.

In: Clinical Biochemistry, Vol. 45, No. 15, 2012, p. 1158-1160.

Research output: Contribution to journalArticle

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AU - Koerbin, Gus

AU - Abhayaratna, W

AU - Potter, Julia

AU - Apostoloska, S

AU - Telford, Richard

AU - Hickman, Peter

PY - 2012

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AB - IntroductionThere have been limited studies generating BNP and NT-proBNP reference intervals for paediatric populations. We prospectively assessed NT-proBNP levels in a cohort of 854 healthy school children from the Lifestyle of Our Kids (LOOK) prospective longitudinal study.Materials and methodsNT-proBNP analysis was performed on 172 girls and 212 boys with average age 8.1 years, 183 girls and 181 boys, average age 10.1 years and 183 girls and 180 boys with average age 11.9 years. Data were stratified according to age and gender with the median, range of results and 2.5th and 97.5th percentiles calculatedResultsThere were no significant differences between males and females at any of the 3 study ages. Significant differences were seen between the 8 and 12 year-olds, 10 and 12 year-olds and the 8 and 12 year-old boys.DiscussionOur study demonstrated that NT-proBNP concentrations in healthy children progressively decline between ages 8 and 12 years. Our selection of unambiguously healthy children produced similar median but lower 97.5th percentile NT-proBNP concentrations to previously published studies

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Koerbin G, Abhayaratna W, Potter J, Apostoloska S, Telford R, Hickman P. NTproBNP concentrations in healthy children. Clinical Biochemistry. 2012;45(15):1158-1160. https://doi.org/10.1016/J.CLINBIOCHEM.2012.05.008