Nuclear transport in Entamoeba histolytica: knowledge gap and therapeutic potential

Marina A Gwairgi, Reena Ghildyal

Research output: Contribution to journalArticle

Abstract

Entamoeba histolytica is the protozoan parasite that causes human amoebiasis. It is one of the leading parasitic disease burdens in tropical regions and developing countries, with spread to developed countries through migrants from and travellers to endemic regions. Understanding E. histolytica's invasion mechanisms requires an understanding of how it interacts with external cell components and how it engulfs and kills cells (phagocytosis). Recent research suggests that optimal phagocytosis requires signalling events from the cell surface to the nucleus via the cytoplasm, and the induction of several factors that are transported to the plasma membrane. Current research in other protozoans suggests the presence of proteins with nuclear localization signals, nuclear export signals and Ran proteins; however, there is limited literature on their functionality and their functional similarity to higher eukaryotes. Based on learnings from the development of antivirals, nuclear transport elements in E. histolytica may present viable, specific, therapeutic targets. In this review, we aim to summarize our limited knowledge of the eukaryotic nuclear transport mechanisms that are conserved and may function in E. histolytica.

Original languageEnglish
Pages (from-to)1378 – 1387
Number of pages10
JournalParasitology
Volume145
Issue number11
DOIs
Publication statusPublished - 22 Mar 2018

Fingerprint

Entamoeba histolytica
Cell Nucleus Active Transport
phagocytosis
therapeutics
Protozoa
ran GTP-Binding Protein
amebiasis
Nuclear Export Signals
Cytophagocytosis
Nuclear Localization Signals
nuclear localization signals
Amebiasis
Parasitic Diseases
burden of disease
cells
Cellular Structures
parasitoses
Eukaryota
Phagocytosis
Research

Cite this

@article{cf5e5a7e5658418ca30cbe83a1c2171e,
title = "Nuclear transport in Entamoeba histolytica: knowledge gap and therapeutic potential",
abstract = "Entamoeba histolytica is the protozoan parasite that causes human amoebiasis. It is one of the leading parasitic disease burdens in tropical regions and developing countries, with spread to developed countries through migrants from and travellers to endemic regions. Understanding E. histolytica's invasion mechanisms requires an understanding of how it interacts with external cell components and how it engulfs and kills cells (phagocytosis). Recent research suggests that optimal phagocytosis requires signalling events from the cell surface to the nucleus via the cytoplasm, and the induction of several factors that are transported to the plasma membrane. Current research in other protozoans suggests the presence of proteins with nuclear localization signals, nuclear export signals and Ran proteins; however, there is limited literature on their functionality and their functional similarity to higher eukaryotes. Based on learnings from the development of antivirals, nuclear transport elements in E. histolytica may present viable, specific, therapeutic targets. In this review, we aim to summarize our limited knowledge of the eukaryotic nuclear transport mechanisms that are conserved and may function in E. histolytica.",
keywords = "Actin-binding proteins, Calcium-Binding Proteins, Entamoeba histolytica, Nuclear Transport",
author = "Gwairgi, {Marina A} and Reena Ghildyal",
year = "2018",
month = "3",
day = "22",
doi = "10.1017/S0031182018000252",
language = "English",
volume = "145",
pages = "1378 – 1387",
journal = "Parasitology",
issn = "0031-1820",
publisher = "Cambridge University Press",
number = "11",

}

Nuclear transport in Entamoeba histolytica: knowledge gap and therapeutic potential. / Gwairgi, Marina A; Ghildyal, Reena.

In: Parasitology, Vol. 145, No. 11, 22.03.2018, p. 1378 – 1387.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nuclear transport in Entamoeba histolytica: knowledge gap and therapeutic potential

AU - Gwairgi, Marina A

AU - Ghildyal, Reena

PY - 2018/3/22

Y1 - 2018/3/22

N2 - Entamoeba histolytica is the protozoan parasite that causes human amoebiasis. It is one of the leading parasitic disease burdens in tropical regions and developing countries, with spread to developed countries through migrants from and travellers to endemic regions. Understanding E. histolytica's invasion mechanisms requires an understanding of how it interacts with external cell components and how it engulfs and kills cells (phagocytosis). Recent research suggests that optimal phagocytosis requires signalling events from the cell surface to the nucleus via the cytoplasm, and the induction of several factors that are transported to the plasma membrane. Current research in other protozoans suggests the presence of proteins with nuclear localization signals, nuclear export signals and Ran proteins; however, there is limited literature on their functionality and their functional similarity to higher eukaryotes. Based on learnings from the development of antivirals, nuclear transport elements in E. histolytica may present viable, specific, therapeutic targets. In this review, we aim to summarize our limited knowledge of the eukaryotic nuclear transport mechanisms that are conserved and may function in E. histolytica.

AB - Entamoeba histolytica is the protozoan parasite that causes human amoebiasis. It is one of the leading parasitic disease burdens in tropical regions and developing countries, with spread to developed countries through migrants from and travellers to endemic regions. Understanding E. histolytica's invasion mechanisms requires an understanding of how it interacts with external cell components and how it engulfs and kills cells (phagocytosis). Recent research suggests that optimal phagocytosis requires signalling events from the cell surface to the nucleus via the cytoplasm, and the induction of several factors that are transported to the plasma membrane. Current research in other protozoans suggests the presence of proteins with nuclear localization signals, nuclear export signals and Ran proteins; however, there is limited literature on their functionality and their functional similarity to higher eukaryotes. Based on learnings from the development of antivirals, nuclear transport elements in E. histolytica may present viable, specific, therapeutic targets. In this review, we aim to summarize our limited knowledge of the eukaryotic nuclear transport mechanisms that are conserved and may function in E. histolytica.

KW - Actin-binding proteins

KW - Calcium-Binding Proteins

KW - Entamoeba histolytica

KW - Nuclear Transport

UR - https://www.cambridge.org/core/journals/parasitology/article/nuclear-transport-in-entamoeba-histolytica-knowledge-gap-and-therapeutic-potential/3AD7AE6F2F52B7E35A25A7BA267671D5#

U2 - 10.1017/S0031182018000252

DO - 10.1017/S0031182018000252

M3 - Article

VL - 145

SP - 1378

EP - 1387

JO - Parasitology

JF - Parasitology

SN - 0031-1820

IS - 11

ER -