Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses

Erin WALKER, Michelle GAHAN, Reena GHILDYAL

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.
    Original languageEnglish
    Pages (from-to)1-10
    Number of pages10
    JournalFrontiers in Microbiology
    Volume6
    Issue numberJUN
    DOIs
    Publication statusPublished - 2015

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    Nucleocytoplasmic Transport Proteins
    Nucleocapsid Proteins
    RNA Viruses
    Life Cycle Stages
    Antiviral Agents
    Cytoplasm
    Cell Nucleolus
    Viruses
    Virus Assembly
    Attenuated Vaccines
    Virus Replication
    Genome
    RNA
    Infection
    Proteins

    Cite this

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    abstract = "Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.",
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    Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses. / WALKER, Erin; GAHAN, Michelle; GHILDYAL, Reena.

    In: Frontiers in Microbiology, Vol. 6, No. JUN, 2015, p. 1-10.

    Research output: Contribution to journalArticle

    TY - JOUR

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    AU - WALKER, Erin

    AU - GAHAN, Michelle

    AU - GHILDYAL, Reena

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    AB - Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.

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