Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses

Wahyu Nawang Wulan, Deborah Heydet, Erin WALKER, Michelle GAHAN, Reena GHILDYAL

Research output: Contribution to journalArticle

15 Citations (Scopus)
1 Downloads (Pure)

Abstract

Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalFrontiers in Microbiology
Volume6
Issue numberJUN
DOIs
Publication statusPublished - 2 Jun 2015

Fingerprint

Nucleocytoplasmic Transport Proteins
Nucleocapsid Proteins
RNA Viruses
Life Cycle Stages
Antiviral Agents
Cytoplasm
Cell Nucleolus
Viruses
Virus Assembly
Attenuated Vaccines
Virus Replication
Genome
RNA
Infection
Proteins

Cite this

Wulan, Wahyu Nawang ; Heydet, Deborah ; WALKER, Erin ; GAHAN, Michelle ; GHILDYAL, Reena. / Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses. In: Frontiers in Microbiology. 2015 ; Vol. 6, No. JUN. pp. 1-10.
@article{22b32968d947447aa20d01ac5b7b11d6,
title = "Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses",
abstract = "Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.",
keywords = "Antiviral responses, Enveloped RNA viruses, Nuclear localization, Nucleocapsid protein, Nucleolar localization",
author = "Wulan, {Wahyu Nawang} and Deborah Heydet and Erin WALKER and Michelle GAHAN and Reena GHILDYAL",
year = "2015",
month = "6",
day = "2",
doi = "10.3389/fmicb.2015.00553",
language = "English",
volume = "6",
pages = "1--10",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S.A.",
number = "JUN",

}

Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses. / Wulan, Wahyu Nawang; Heydet, Deborah; WALKER, Erin; GAHAN, Michelle; GHILDYAL, Reena.

In: Frontiers in Microbiology, Vol. 6, No. JUN, 02.06.2015, p. 1-10.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses

AU - Wulan, Wahyu Nawang

AU - Heydet, Deborah

AU - WALKER, Erin

AU - GAHAN, Michelle

AU - GHILDYAL, Reena

PY - 2015/6/2

Y1 - 2015/6/2

N2 - Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.

AB - Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.

KW - Antiviral responses

KW - Enveloped RNA viruses

KW - Nuclear localization

KW - Nucleocapsid protein

KW - Nucleolar localization

UR - http://www.scopus.com/inward/record.url?scp=84937003478&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2015.00553

DO - 10.3389/fmicb.2015.00553

M3 - Article

VL - 6

SP - 1

EP - 10

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

IS - JUN

ER -