Nutritional control of reproductive status in honeybees via DNA methylation

R. Kucharski, J. Maleszka, S. Foret, R. Maleszka

Research output: Contribution to journalArticle

672 Citations (Scopus)

Abstract

Fertile queens and sterile workers are alternative forms of the adult female honeybee that develop from genetically identical larvae following differential feeding with royal jelly. We show that silencing the expression of DNA methyltransferase Dnmt3, a key driver of epigenetic global reprogramming, in newly hatched larvae led to a royal jelly–like effect on the larval developmental trajectory; the majority of Dnmt3 small interfering RNA–treated individuals emerged as queens with fully developed ovaries. Our results suggest that DNA methylation in Apis is used for storing epigenetic information, that the use of that information can be differentially altered by nutritional input, and that the flexibility of epigenetic modifications underpins, profound shifts in developmental fates, with massive implications for reproductive and behavioral status
Original languageEnglish
Pages (from-to)1827-1830
Number of pages4
JournalScience
Volume319
Issue number5871
DOIs
Publication statusPublished - 28 Mar 2008
Externally publishedYes

Cite this

Kucharski, R., Maleszka, J., Foret, S., & Maleszka, R. (2008). Nutritional control of reproductive status in honeybees via DNA methylation. Science, 319(5871), 1827-1830. https://doi.org/10.1126/science.1153069
Kucharski, R. ; Maleszka, J. ; Foret, S. ; Maleszka, R. / Nutritional control of reproductive status in honeybees via DNA methylation. In: Science. 2008 ; Vol. 319, No. 5871. pp. 1827-1830.
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Kucharski, R, Maleszka, J, Foret, S & Maleszka, R 2008, 'Nutritional control of reproductive status in honeybees via DNA methylation', Science, vol. 319, no. 5871, pp. 1827-1830. https://doi.org/10.1126/science.1153069

Nutritional control of reproductive status in honeybees via DNA methylation. / Kucharski, R.; Maleszka, J.; Foret, S.; Maleszka, R.

In: Science, Vol. 319, No. 5871, 28.03.2008, p. 1827-1830.

Research output: Contribution to journalArticle

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AB - Fertile queens and sterile workers are alternative forms of the adult female honeybee that develop from genetically identical larvae following differential feeding with royal jelly. We show that silencing the expression of DNA methyltransferase Dnmt3, a key driver of epigenetic global reprogramming, in newly hatched larvae led to a royal jelly–like effect on the larval developmental trajectory; the majority of Dnmt3 small interfering RNA–treated individuals emerged as queens with fully developed ovaries. Our results suggest that DNA methylation in Apis is used for storing epigenetic information, that the use of that information can be differentially altered by nutritional input, and that the flexibility of epigenetic modifications underpins, profound shifts in developmental fates, with massive implications for reproductive and behavioral status

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Kucharski R, Maleszka J, Foret S, Maleszka R. Nutritional control of reproductive status in honeybees via DNA methylation. Science. 2008 Mar 28;319(5871):1827-1830. https://doi.org/10.1126/science.1153069