Objective testing of both visual fields in 80 seconds

Faran SABETI, Corinne Carle, Rachel Jaros, Emilie Rohan, Christian J. Lueck, Gordon WADDINGTON, Ted Maddess

Research output: Contribution to conference (non-published works)Poster

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Abstract

Purpose: We compare the signal-to-noise ratios of a higher-resolution multifocal pupillographic perimetry (mfPOP) method that assess both eyes concurrently in 6 minutes, with two new 80-second tests, that have fewer test regions. The gain control of the pupillary system means that larger responses are given when there are fewer stimuli. The study is in the context of an examination of the effects of sports-related concussion but the main outcome measure is the difference in the SNRs between the mfPOP methods. That being said RNFL losses have been reported in mild sports concussion, and Matrix field defects in more serious cases. Methods: We enrolled 54 men, 36 of which were rugby players with a history of concussion that was serious enough to warrant removal from the field. The 18 normal control subjects were aged 22.3 ± 2.38 y and the concussed athletes 21.6 ± 2.11 y (mean ± SD). The concussed athletes were dived into 3 groups (12 per group) that had mean periods since concussion of 16, 311, and 1443 days (acute, chronic, long-term). We also recruited 10 athletes with no history of head injury (22.3 ± 2.4 years). All three stimulus arrays occupied the central 60 degrees of each eye. The high resolution test (P129) had 44 regions per eye (Fig. 2A) and duration 6 minutes. The two 80-second methods (P137 and P138) tested 12 regions/eye (Fig. 2B) and had highest luminances of 156 and 216 cd/m2 respectively. The multifocal response estimation process provided a t-statistic based SNR (t-SNR) for each tested region. The input variable for analysis (Matlab 2016b) was the mean t-SNR for each subject (computed across test-regions, eyes, and pupils). Linear models estimated the differences in SNRs between mfPOP methods and the independent effects of concussion.Retults:The mean t-SNRS for P129, P137 and P138 were 4.01, 5.59, 5.87 (with SE of 0.18). The t-SNRs of P137 and P138 were significantly larger than those of P129 at p<1e-13 (t-stats 8.73 and 10.3 respectively). Across the protocols the linear models indicated that: The acute concussion group had t-SNRs -0.56 lower than controls (p=0.006)Those with chronic concussion at a mean of 311 days had greater t-SNRs by 0.47 (p<0.021), those with long-term concussion at a mean of 1443 days were not different from controls (p=0.93). Conclusion: The coarser 80-second stimuli provided significantly higher signal-to-noise ratios than the higher resolution mfPOP test. This greater accuracy might balance the effects of coarser resolution somewhat. All the tests seemed to have some capacity to detect concussion occurring within 34 days. There is good evidence of pupillary responses to transient stimuli being driven by extra-striate cortex. Thus it is not surprising to find effects of concussion.
Original languageEnglish
Pages1-1
Number of pages1
Publication statusPublished - 2019
Event8th World Glaucoma Congress - Melbourne Convention and Exhibition Centre (MCEC), Melbourne, Australia
Duration: 27 Mar 201930 Mar 2019
https://www.worldglaucomacongress.org/ (Homepage)

Conference

Conference8th World Glaucoma Congress
CountryAustralia
CityMelbourne
Period27/03/1930/03/19
Internet address

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Visual Fields
Visual Field Tests
Athletes
Signal-To-Noise Ratio
Sports
Linear Models
Brain Concussion
Football
Visual Cortex
Pupil
Craniocerebral Trauma
Outcome Assessment (Health Care)

Cite this

SABETI, F., Carle, C., Jaros, R., Rohan, E., Lueck, C. J., WADDINGTON, G., & Maddess, T. (2019). Objective testing of both visual fields in 80 seconds. 1-1. Poster session presented at 8th World Glaucoma Congress, Melbourne, Australia.
SABETI, Faran ; Carle, Corinne ; Jaros, Rachel ; Rohan, Emilie ; Lueck, Christian J. ; WADDINGTON, Gordon ; Maddess, Ted. / Objective testing of both visual fields in 80 seconds. Poster session presented at 8th World Glaucoma Congress, Melbourne, Australia.1 p.
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abstract = "Purpose: We compare the signal-to-noise ratios of a higher-resolution multifocal pupillographic perimetry (mfPOP) method that assess both eyes concurrently in 6 minutes, with two new 80-second tests, that have fewer test regions. The gain control of the pupillary system means that larger responses are given when there are fewer stimuli. The study is in the context of an examination of the effects of sports-related concussion but the main outcome measure is the difference in the SNRs between the mfPOP methods. That being said RNFL losses have been reported in mild sports concussion, and Matrix field defects in more serious cases. Methods: We enrolled 54 men, 36 of which were rugby players with a history of concussion that was serious enough to warrant removal from the field. The 18 normal control subjects were aged 22.3 ± 2.38 y and the concussed athletes 21.6 ± 2.11 y (mean ± SD). The concussed athletes were dived into 3 groups (12 per group) that had mean periods since concussion of 16, 311, and 1443 days (acute, chronic, long-term). We also recruited 10 athletes with no history of head injury (22.3 ± 2.4 years). All three stimulus arrays occupied the central 60 degrees of each eye. The high resolution test (P129) had 44 regions per eye (Fig. 2A) and duration 6 minutes. The two 80-second methods (P137 and P138) tested 12 regions/eye (Fig. 2B) and had highest luminances of 156 and 216 cd/m2 respectively. The multifocal response estimation process provided a t-statistic based SNR (t-SNR) for each tested region. The input variable for analysis (Matlab 2016b) was the mean t-SNR for each subject (computed across test-regions, eyes, and pupils). Linear models estimated the differences in SNRs between mfPOP methods and the independent effects of concussion.Retults:The mean t-SNRS for P129, P137 and P138 were 4.01, 5.59, 5.87 (with SE of 0.18). The t-SNRs of P137 and P138 were significantly larger than those of P129 at p<1e-13 (t-stats 8.73 and 10.3 respectively). Across the protocols the linear models indicated that: The acute concussion group had t-SNRs -0.56 lower than controls (p=0.006)Those with chronic concussion at a mean of 311 days had greater t-SNRs by 0.47 (p<0.021), those with long-term concussion at a mean of 1443 days were not different from controls (p=0.93). Conclusion: The coarser 80-second stimuli provided significantly higher signal-to-noise ratios than the higher resolution mfPOP test. This greater accuracy might balance the effects of coarser resolution somewhat. All the tests seemed to have some capacity to detect concussion occurring within 34 days. There is good evidence of pupillary responses to transient stimuli being driven by extra-striate cortex. Thus it is not surprising to find effects of concussion.",
author = "Faran SABETI and Corinne Carle and Rachel Jaros and Emilie Rohan and Lueck, {Christian J.} and Gordon WADDINGTON and Ted Maddess",
year = "2019",
language = "English",
pages = "1--1",
note = "8th World Glaucoma Congress ; Conference date: 27-03-2019 Through 30-03-2019",
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SABETI, F, Carle, C, Jaros, R, Rohan, E, Lueck, CJ, WADDINGTON, G & Maddess, T 2019, 'Objective testing of both visual fields in 80 seconds' 8th World Glaucoma Congress, Melbourne, Australia, 27/03/19 - 30/03/19, pp. 1-1.

Objective testing of both visual fields in 80 seconds. / SABETI, Faran; Carle, Corinne; Jaros, Rachel; Rohan, Emilie; Lueck, Christian J.; WADDINGTON, Gordon; Maddess, Ted.

2019. 1-1 Poster session presented at 8th World Glaucoma Congress, Melbourne, Australia.

Research output: Contribution to conference (non-published works)Poster

TY - CONF

T1 - Objective testing of both visual fields in 80 seconds

AU - SABETI, Faran

AU - Carle, Corinne

AU - Jaros, Rachel

AU - Rohan, Emilie

AU - Lueck, Christian J.

AU - WADDINGTON, Gordon

AU - Maddess, Ted

PY - 2019

Y1 - 2019

N2 - Purpose: We compare the signal-to-noise ratios of a higher-resolution multifocal pupillographic perimetry (mfPOP) method that assess both eyes concurrently in 6 minutes, with two new 80-second tests, that have fewer test regions. The gain control of the pupillary system means that larger responses are given when there are fewer stimuli. The study is in the context of an examination of the effects of sports-related concussion but the main outcome measure is the difference in the SNRs between the mfPOP methods. That being said RNFL losses have been reported in mild sports concussion, and Matrix field defects in more serious cases. Methods: We enrolled 54 men, 36 of which were rugby players with a history of concussion that was serious enough to warrant removal from the field. The 18 normal control subjects were aged 22.3 ± 2.38 y and the concussed athletes 21.6 ± 2.11 y (mean ± SD). The concussed athletes were dived into 3 groups (12 per group) that had mean periods since concussion of 16, 311, and 1443 days (acute, chronic, long-term). We also recruited 10 athletes with no history of head injury (22.3 ± 2.4 years). All three stimulus arrays occupied the central 60 degrees of each eye. The high resolution test (P129) had 44 regions per eye (Fig. 2A) and duration 6 minutes. The two 80-second methods (P137 and P138) tested 12 regions/eye (Fig. 2B) and had highest luminances of 156 and 216 cd/m2 respectively. The multifocal response estimation process provided a t-statistic based SNR (t-SNR) for each tested region. The input variable for analysis (Matlab 2016b) was the mean t-SNR for each subject (computed across test-regions, eyes, and pupils). Linear models estimated the differences in SNRs between mfPOP methods and the independent effects of concussion.Retults:The mean t-SNRS for P129, P137 and P138 were 4.01, 5.59, 5.87 (with SE of 0.18). The t-SNRs of P137 and P138 were significantly larger than those of P129 at p<1e-13 (t-stats 8.73 and 10.3 respectively). Across the protocols the linear models indicated that: The acute concussion group had t-SNRs -0.56 lower than controls (p=0.006)Those with chronic concussion at a mean of 311 days had greater t-SNRs by 0.47 (p<0.021), those with long-term concussion at a mean of 1443 days were not different from controls (p=0.93). Conclusion: The coarser 80-second stimuli provided significantly higher signal-to-noise ratios than the higher resolution mfPOP test. This greater accuracy might balance the effects of coarser resolution somewhat. All the tests seemed to have some capacity to detect concussion occurring within 34 days. There is good evidence of pupillary responses to transient stimuli being driven by extra-striate cortex. Thus it is not surprising to find effects of concussion.

AB - Purpose: We compare the signal-to-noise ratios of a higher-resolution multifocal pupillographic perimetry (mfPOP) method that assess both eyes concurrently in 6 minutes, with two new 80-second tests, that have fewer test regions. The gain control of the pupillary system means that larger responses are given when there are fewer stimuli. The study is in the context of an examination of the effects of sports-related concussion but the main outcome measure is the difference in the SNRs between the mfPOP methods. That being said RNFL losses have been reported in mild sports concussion, and Matrix field defects in more serious cases. Methods: We enrolled 54 men, 36 of which were rugby players with a history of concussion that was serious enough to warrant removal from the field. The 18 normal control subjects were aged 22.3 ± 2.38 y and the concussed athletes 21.6 ± 2.11 y (mean ± SD). The concussed athletes were dived into 3 groups (12 per group) that had mean periods since concussion of 16, 311, and 1443 days (acute, chronic, long-term). We also recruited 10 athletes with no history of head injury (22.3 ± 2.4 years). All three stimulus arrays occupied the central 60 degrees of each eye. The high resolution test (P129) had 44 regions per eye (Fig. 2A) and duration 6 minutes. The two 80-second methods (P137 and P138) tested 12 regions/eye (Fig. 2B) and had highest luminances of 156 and 216 cd/m2 respectively. The multifocal response estimation process provided a t-statistic based SNR (t-SNR) for each tested region. The input variable for analysis (Matlab 2016b) was the mean t-SNR for each subject (computed across test-regions, eyes, and pupils). Linear models estimated the differences in SNRs between mfPOP methods and the independent effects of concussion.Retults:The mean t-SNRS for P129, P137 and P138 were 4.01, 5.59, 5.87 (with SE of 0.18). The t-SNRs of P137 and P138 were significantly larger than those of P129 at p<1e-13 (t-stats 8.73 and 10.3 respectively). Across the protocols the linear models indicated that: The acute concussion group had t-SNRs -0.56 lower than controls (p=0.006)Those with chronic concussion at a mean of 311 days had greater t-SNRs by 0.47 (p<0.021), those with long-term concussion at a mean of 1443 days were not different from controls (p=0.93). Conclusion: The coarser 80-second stimuli provided significantly higher signal-to-noise ratios than the higher resolution mfPOP test. This greater accuracy might balance the effects of coarser resolution somewhat. All the tests seemed to have some capacity to detect concussion occurring within 34 days. There is good evidence of pupillary responses to transient stimuli being driven by extra-striate cortex. Thus it is not surprising to find effects of concussion.

M3 - Poster

SP - 1

EP - 1

ER -

SABETI F, Carle C, Jaros R, Rohan E, Lueck CJ, WADDINGTON G et al. Objective testing of both visual fields in 80 seconds. 2019. Poster session presented at 8th World Glaucoma Congress, Melbourne, Australia.