Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs

D L Clarke, A McKune, S R Thomson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. Methods: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. Results: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. Conclusions: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.

Original languageEnglish
Pages (from-to)1570-1572
Number of pages3
JournalSurgical Endoscopy: surgical and interventional techniques
Volume17
Issue number10
DOIs
Publication statusPublished - 2003
Externally publishedYes

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Octreotide
Stomach
Laser-Doppler Flowmetry
Viscera
Portal Hypertension
Gastrointestinal Agents
Healthy Volunteers
Lasers
Hemorrhage
Peptides

Cite this

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title = "Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs",
abstract = "Background: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. Methods: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. Results: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. Conclusions: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.",
keywords = "Adult, Female, Gastric Mucosa, Gastrointestinal Agents, Humans, Hypertension, Portal, Laser-Doppler Flowmetry, Male, Monitoring, Physiologic, Octreotide, Regional Blood Flow, Splanchnic Circulation, Clinical Trial, Controlled Clinical Trial, Journal Article",
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Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs. / Clarke, D L; McKune, A; Thomson, S R.

In: Surgical Endoscopy: surgical and interventional techniques, Vol. 17, No. 10, 2003, p. 1570-1572.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs

AU - Clarke, D L

AU - McKune, A

AU - Thomson, S R

PY - 2003

Y1 - 2003

N2 - Background: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. Methods: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. Results: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. Conclusions: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.

AB - Background: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. Methods: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. Results: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. Conclusions: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.

KW - Adult

KW - Female

KW - Gastric Mucosa

KW - Gastrointestinal Agents

KW - Humans

KW - Hypertension, Portal

KW - Laser-Doppler Flowmetry

KW - Male

KW - Monitoring, Physiologic

KW - Octreotide

KW - Regional Blood Flow

KW - Splanchnic Circulation

KW - Clinical Trial

KW - Controlled Clinical Trial

KW - Journal Article

U2 - 10.1007/s00464-002-9274-z

DO - 10.1007/s00464-002-9274-z

M3 - Article

VL - 17

SP - 1570

EP - 1572

JO - Surgical Endoscopy

JF - Surgical Endoscopy

SN - 0930-2794

IS - 10

ER -