Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs

D L Clarke; A McKune; S R Thomson

doi:10.1007/s00464-002-9274-z

Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs

D L Clarke, A McKune, S R Thomson

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. Methods: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. Results: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. Conclusions: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.

Original language	English
Pages (from-to)	1570-1572
Number of pages	3
Journal	Surgical Endoscopy: surgical and interventional techniques
Volume	17
Issue number	10
DOIs	https://doi.org/10.1007/s00464-002-9274-z
Publication status	Published - 2003
Externally published	Yes

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10.1007/s00464-002-9274-z

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@article{088e2db0b9d64c9195de47764cef33cc,

title = "Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs",

abstract = "Background: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. Methods: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. Results: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. Conclusions: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.",

keywords = "Adult, Female, Gastric Mucosa, Gastrointestinal Agents, Humans, Hypertension, Portal, Laser-Doppler Flowmetry, Male, Monitoring, Physiologic, Octreotide, Regional Blood Flow, Splanchnic Circulation, Clinical Trial, Controlled Clinical Trial, Journal Article",

author = "Clarke, {D L} and A McKune and Thomson, {S R}",

year = "2003",

doi = "10.1007/s00464-002-9274-z",

language = "English",

volume = "17",

pages = "1570--1572",

journal = "Surgical Endoscopy: surgical and interventional techniques",

issn = "0930-2794",

publisher = "Springer",

number = "10",

}

TY - JOUR

T1 - Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs

AU - Clarke, D L

AU - McKune, A

AU - Thomson, S R

PY - 2003

Y1 - 2003

N2 - Background: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. Methods: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. Results: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. Conclusions: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.

AB - Background: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. Methods: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. Results: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. Conclusions: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.

KW - Adult

KW - Female

KW - Gastric Mucosa

KW - Gastrointestinal Agents

KW - Humans

KW - Hypertension, Portal

KW - Laser-Doppler Flowmetry

KW - Male

KW - Monitoring, Physiologic

KW - Octreotide

KW - Regional Blood Flow

KW - Splanchnic Circulation

KW - Clinical Trial

KW - Controlled Clinical Trial

KW - Journal Article

U2 - 10.1007/s00464-002-9274-z

DO - 10.1007/s00464-002-9274-z

M3 - Article

C2 - 12874677

SN - 0930-2794

VL - 17

SP - 1570

EP - 1572

JO - Surgical Endoscopy: surgical and interventional techniques

JF - Surgical Endoscopy: surgical and interventional techniques

IS - 10

ER -

Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs

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