On Regenerating the Ovary and Generating Controversy

Evelyn E. Telfer, Roger G. Gosden, Anne Grete Byskov, Norah Spears, David Albertini, Claus Yding Andersen, Richard Anderson, Ruth Braw-Tal, Hugh Clarke, Alain Gougeon, Eileen McLaughlin, Anne McLaren, Kenneth McNatty, Gerald Schatten, Sherman Silber, Alex Tsafriri

Research output: Contribution to journalLetter

118 Citations (Scopus)

Abstract

For more than a half a century, biologists have upheld the theory that in most mammalian species, oocytes are formed before or shortly after birth, but never in adulthood. This foundation of reproductive science has survived the rapid growth of new technology and knowledge and has remained virtually unchallenged until two recent papers were published by the group headed by Jonathan Tilly. The first paper claims that mouse germline stem cells (GSCs) replace ovarian follicles that have been rapidly lost through follicle death (Johnson et al., 2004). The second paper, recently published in Cell, proposes continuous immigration into mouse ovaries of GSCs derived from bone marrow (Johnson et al., 2005). How could so many investigators have overlooked these basic mechanisms for so long, or have they?
Original languageEnglish
Pages (from-to)821-822
Number of pages2
JournalCell
Volume122
Issue number6
DOIs
Publication statusPublished - 23 Sep 2005
Externally publishedYes

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Stem cells
Ovary
Stem Cells
Ovarian Follicle
Emigration and Immigration
Oocytes
Bone
Bone Marrow
Research Personnel
Parturition
Technology
Growth

Cite this

Telfer, E. E., Gosden, R. G., Byskov, A. G., Spears, N., Albertini, D., Andersen, C. Y., ... Tsafriri, A. (2005). On Regenerating the Ovary and Generating Controversy. Cell, 122(6), 821-822. https://doi.org/10.1016/j.cell.2005.09.004
Telfer, Evelyn E. ; Gosden, Roger G. ; Byskov, Anne Grete ; Spears, Norah ; Albertini, David ; Andersen, Claus Yding ; Anderson, Richard ; Braw-Tal, Ruth ; Clarke, Hugh ; Gougeon, Alain ; McLaughlin, Eileen ; McLaren, Anne ; McNatty, Kenneth ; Schatten, Gerald ; Silber, Sherman ; Tsafriri, Alex. / On Regenerating the Ovary and Generating Controversy. In: Cell. 2005 ; Vol. 122, No. 6. pp. 821-822.
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Telfer, EE, Gosden, RG, Byskov, AG, Spears, N, Albertini, D, Andersen, CY, Anderson, R, Braw-Tal, R, Clarke, H, Gougeon, A, McLaughlin, E, McLaren, A, McNatty, K, Schatten, G, Silber, S & Tsafriri, A 2005, 'On Regenerating the Ovary and Generating Controversy', Cell, vol. 122, no. 6, pp. 821-822. https://doi.org/10.1016/j.cell.2005.09.004

On Regenerating the Ovary and Generating Controversy. / Telfer, Evelyn E.; Gosden, Roger G.; Byskov, Anne Grete; Spears, Norah; Albertini, David; Andersen, Claus Yding; Anderson, Richard; Braw-Tal, Ruth; Clarke, Hugh; Gougeon, Alain; McLaughlin, Eileen; McLaren, Anne; McNatty, Kenneth; Schatten, Gerald; Silber, Sherman; Tsafriri, Alex.

In: Cell, Vol. 122, No. 6, 23.09.2005, p. 821-822.

Research output: Contribution to journalLetter

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Telfer EE, Gosden RG, Byskov AG, Spears N, Albertini D, Andersen CY et al. On Regenerating the Ovary and Generating Controversy. Cell. 2005 Sep 23;122(6):821-822. https://doi.org/10.1016/j.cell.2005.09.004