The uncertainty principle is one of the most important features in modeling and solving linear time-invariant (LTI) systems. The neutrality phenomena of some factors in real models have been widely recognized by engineers and scientists. The convenience and flexibility of neutrosophic theory in the description and differentiation of uncertainty terms make it take advantage of modeling and designing of control systems. This paper deals with the controllability and stabilizability of LTI systems containing neutrosophic uncertainty in the sense of both indeterminacy parameters and functional relationships. We define some properties and operators between neutrosophic numbers via horizontal membership function of a relative-distance-measure variable. Results on exponential matrices of neutrosophic numbers are well-defined with the notion etA deployed in a series of neutrosophic matrices. Moreover, we introduce the concepts of controllability and stabilizability of neutrosophic systems in the sense of Granular derivatives. Sufficient conditions to guarantee the controllability of neutrosophic LTI systems are established. Some numerical examples, related to RLC circuit and DC motor systems, are exhibited to illustrate the effectiveness of theoretical results.