Optimization of Oral Immunization through receptor-mediated targeting of M cells

Ruth Foxwell, Allan W. Cripps, Jenelle Maree KYD

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Only a small number of oral vaccines are available for routine immunisations despite a significant research effort and a number of obvious advantages over parenteral vaccination. The major roadblock in the development of oral vaccines has been mostly attributed to a lack of ability to specifically target antigen to the mucosal immune system of the gastrointestinal tract. This commentary examines the accessing of M cells through receptor interaction on the apical surface of the cell in order to enhance the efficiency and efficacy of oral immunisation. Three challenges have been identified (i) the availability of appropriate experimental models to study M cell targeting and transcytosis; (ii) appropriate tools for investigating the specificity of targeting; and (iii) the identification of priority targets on the apical surface of M cells.
    Original languageEnglish
    Pages (from-to)220-223
    Number of pages4
    JournalHuman Vaccines and Immunotherapeutics
    Volume3
    Issue number5
    DOIs
    Publication statusPublished - 2007

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