Optimization of Oral Immunization through receptor-mediated targeting of M cells

Ruth Foxwell, Allan W. Cripps, Jenelle Maree KYD

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Only a small number of oral vaccines are available for routine immunisations despite a significant research effort and a number of obvious advantages over parenteral vaccination. The major roadblock in the development of oral vaccines has been mostly attributed to a lack of ability to specifically target antigen to the mucosal immune system of the gastrointestinal tract. This commentary examines the accessing of M cells through receptor interaction on the apical surface of the cell in order to enhance the efficiency and efficacy of oral immunisation. Three challenges have been identified (i) the availability of appropriate experimental models to study M cell targeting and transcytosis; (ii) appropriate tools for investigating the specificity of targeting; and (iii) the identification of priority targets on the apical surface of M cells.
    Original languageEnglish
    Pages (from-to)220-223
    Number of pages4
    JournalHuman Vaccines and Immunotherapeutics
    Volume3
    Issue number5
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    Immunization
    Vaccines
    Transcytosis
    Gastrointestinal Tract
    Immune System
    Vaccination
    Theoretical Models
    Antigens
    Research

    Cite this

    Foxwell, Ruth ; Cripps, Allan W. ; KYD, Jenelle Maree. / Optimization of Oral Immunization through receptor-mediated targeting of M cells. In: Human Vaccines and Immunotherapeutics. 2007 ; Vol. 3, No. 5. pp. 220-223.
    @article{c3f2ab1e488d4a6d978aad130f30fb02,
    title = "Optimization of Oral Immunization through receptor-mediated targeting of M cells",
    abstract = "Only a small number of oral vaccines are available for routine immunisations despite a significant research effort and a number of obvious advantages over parenteral vaccination. The major roadblock in the development of oral vaccines has been mostly attributed to a lack of ability to specifically target antigen to the mucosal immune system of the gastrointestinal tract. This commentary examines the accessing of M cells through receptor interaction on the apical surface of the cell in order to enhance the efficiency and efficacy of oral immunisation. Three challenges have been identified (i) the availability of appropriate experimental models to study M cell targeting and transcytosis; (ii) appropriate tools for investigating the specificity of targeting; and (iii) the identification of priority targets on the apical surface of M cells.",
    author = "Ruth Foxwell and Cripps, {Allan W.} and KYD, {Jenelle Maree}",
    year = "2007",
    doi = "10.4161/hv.3.5.4358",
    language = "English",
    volume = "3",
    pages = "220--223",
    journal = "Human Vaccines and Immunotherapeutics",
    issn = "1554-8600",
    publisher = "Landes Bioscience",
    number = "5",

    }

    Optimization of Oral Immunization through receptor-mediated targeting of M cells. / Foxwell, Ruth; Cripps, Allan W.; KYD, Jenelle Maree.

    In: Human Vaccines and Immunotherapeutics, Vol. 3, No. 5, 2007, p. 220-223.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Optimization of Oral Immunization through receptor-mediated targeting of M cells

    AU - Foxwell, Ruth

    AU - Cripps, Allan W.

    AU - KYD, Jenelle Maree

    PY - 2007

    Y1 - 2007

    N2 - Only a small number of oral vaccines are available for routine immunisations despite a significant research effort and a number of obvious advantages over parenteral vaccination. The major roadblock in the development of oral vaccines has been mostly attributed to a lack of ability to specifically target antigen to the mucosal immune system of the gastrointestinal tract. This commentary examines the accessing of M cells through receptor interaction on the apical surface of the cell in order to enhance the efficiency and efficacy of oral immunisation. Three challenges have been identified (i) the availability of appropriate experimental models to study M cell targeting and transcytosis; (ii) appropriate tools for investigating the specificity of targeting; and (iii) the identification of priority targets on the apical surface of M cells.

    AB - Only a small number of oral vaccines are available for routine immunisations despite a significant research effort and a number of obvious advantages over parenteral vaccination. The major roadblock in the development of oral vaccines has been mostly attributed to a lack of ability to specifically target antigen to the mucosal immune system of the gastrointestinal tract. This commentary examines the accessing of M cells through receptor interaction on the apical surface of the cell in order to enhance the efficiency and efficacy of oral immunisation. Three challenges have been identified (i) the availability of appropriate experimental models to study M cell targeting and transcytosis; (ii) appropriate tools for investigating the specificity of targeting; and (iii) the identification of priority targets on the apical surface of M cells.

    U2 - 10.4161/hv.3.5.4358

    DO - 10.4161/hv.3.5.4358

    M3 - Article

    VL - 3

    SP - 220

    EP - 223

    JO - Human Vaccines and Immunotherapeutics

    JF - Human Vaccines and Immunotherapeutics

    SN - 1554-8600

    IS - 5

    ER -