Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in achilles tendinopathy patients

Stephan F.E. Praet, Craig R. Purdam, Marijke Welvaert, Nicole Vlahovich, Gregg Lovell, Louise M. Burke, Jamie E. Gaida, Silvia Manzanero, David Hughes, Gordon Waddington

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    Abstract

    The current pilot study investigates whether oral supplementation of specific collagen peptides improves symptoms and tendon vascularisation in patients with chronic mid-portion Achilles tendinopathy in combination with structured exercise. Participants were given a placebo or specific collagen peptides (TENDOFORTE®) in combination with a bi-daily calf-strengthening program for 6 months. Group AB received specific collagen peptides for the first 3 months before crossing over to placebo. Group BA received placebo first before crossing over to specific collagen peptides. At baseline (T1), 3 (T2) and 6 (T3) months, Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaires and microvascularity measurements through contrast-enhanced ultrasound were obtained in 20 patients. Linear mixed modeling statistics showed that after 3 months, VISA-A increased significantly for group AB with 12.6 (9.7; 15.5), while in group BA VISA-A increased only by 5.3 (2.3; 8.3) points. After crossing over group AB and BA showed subsequently a significant increase in VISA-A of, respectively, 5.9 (2.8; 9.0) and 17.7 (14.6; 20.7). No adverse advents were reported. Microvascularity decreased in both groups to a similar extent and was moderately associated with VISA-A (Rc 2:0.68). We conclude that oral supplementation of specific collagen peptides may accelerate the clinical benefits of a well-structured calf-strengthening and return-to-running program in Achilles tendinopathy patients.

    Original languageEnglish
    Article number76
    JournalNutrients
    Volume11
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2019

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    Tendinopathy
    sports
    Sports
    collagen
    pain
    mouth
    exercise
    Collagen
    calves
    peptides
    Exercise
    crossing over
    Pain
    Peptides
    placebos
    Placebos
    tendons
    Running
    Tendons
    signs and symptoms (animals and humans)

    Cite this

    Praet, Stephan F.E. ; Purdam, Craig R. ; Welvaert, Marijke ; Vlahovich, Nicole ; Lovell, Gregg ; Burke, Louise M. ; Gaida, Jamie E. ; Manzanero, Silvia ; Hughes, David ; Waddington, Gordon. / Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in achilles tendinopathy patients. In: Nutrients. 2019 ; Vol. 11, No. 1.
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    abstract = "The current pilot study investigates whether oral supplementation of specific collagen peptides improves symptoms and tendon vascularisation in patients with chronic mid-portion Achilles tendinopathy in combination with structured exercise. Participants were given a placebo or specific collagen peptides (TENDOFORTE{\circledR}) in combination with a bi-daily calf-strengthening program for 6 months. Group AB received specific collagen peptides for the first 3 months before crossing over to placebo. Group BA received placebo first before crossing over to specific collagen peptides. At baseline (T1), 3 (T2) and 6 (T3) months, Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaires and microvascularity measurements through contrast-enhanced ultrasound were obtained in 20 patients. Linear mixed modeling statistics showed that after 3 months, VISA-A increased significantly for group AB with 12.6 (9.7; 15.5), while in group BA VISA-A increased only by 5.3 (2.3; 8.3) points. After crossing over group AB and BA showed subsequently a significant increase in VISA-A of, respectively, 5.9 (2.8; 9.0) and 17.7 (14.6; 20.7). No adverse advents were reported. Microvascularity decreased in both groups to a similar extent and was moderately associated with VISA-A (Rc 2:0.68). We conclude that oral supplementation of specific collagen peptides may accelerate the clinical benefits of a well-structured calf-strengthening and return-to-running program in Achilles tendinopathy patients.",
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    Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in achilles tendinopathy patients. / Praet, Stephan F.E.; Purdam, Craig R.; Welvaert, Marijke; Vlahovich, Nicole; Lovell, Gregg; Burke, Louise M.; Gaida, Jamie E.; Manzanero, Silvia; Hughes, David; Waddington, Gordon.

    In: Nutrients, Vol. 11, No. 1, 76, 01.01.2019.

    Research output: Contribution to journalArticle

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    AU - Praet, Stephan F.E.

    AU - Purdam, Craig R.

    AU - Welvaert, Marijke

    AU - Vlahovich, Nicole

    AU - Lovell, Gregg

    AU - Burke, Louise M.

    AU - Gaida, Jamie E.

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    AU - Hughes, David

    AU - Waddington, Gordon

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    AB - The current pilot study investigates whether oral supplementation of specific collagen peptides improves symptoms and tendon vascularisation in patients with chronic mid-portion Achilles tendinopathy in combination with structured exercise. Participants were given a placebo or specific collagen peptides (TENDOFORTE®) in combination with a bi-daily calf-strengthening program for 6 months. Group AB received specific collagen peptides for the first 3 months before crossing over to placebo. Group BA received placebo first before crossing over to specific collagen peptides. At baseline (T1), 3 (T2) and 6 (T3) months, Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaires and microvascularity measurements through contrast-enhanced ultrasound were obtained in 20 patients. Linear mixed modeling statistics showed that after 3 months, VISA-A increased significantly for group AB with 12.6 (9.7; 15.5), while in group BA VISA-A increased only by 5.3 (2.3; 8.3) points. After crossing over group AB and BA showed subsequently a significant increase in VISA-A of, respectively, 5.9 (2.8; 9.0) and 17.7 (14.6; 20.7). No adverse advents were reported. Microvascularity decreased in both groups to a similar extent and was moderately associated with VISA-A (Rc 2:0.68). We conclude that oral supplementation of specific collagen peptides may accelerate the clinical benefits of a well-structured calf-strengthening and return-to-running program in Achilles tendinopathy patients.

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    KW - Microvessels

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