@article{c7d6ea2ce4784f52b8f962a3e4fc42a7,
title = "Osteoarthritis year in review 2023: Biomechanics",
abstract = "Biomechanics plays a significant yet complex role in osteoarthritis (OA) onset and progression. Identifying alterations in biomechanical factors and their complex interactions is critical for gaining new insights into OA pathophysiology and identification of clearly defined and modifiable mechanical treatment targets. This review synthesized biomechanics studies from March 2022 to April 2023, from which three themes relating to human gait emerged: (1) new insights into the pathogenesis of OA using computational modeling and machine learning, (2) technology-enhanced biomechanical interventions for OA, and (3) out-of-lab biomechanical assessments of OA. We further highlighted future-focused areas which may continue to advance the field of biomechanics in OA, with a particular emphasis on exploiting technology to understand and treat biomechanical mechanisms of OA outside the laboratory. The breadth of studies included in this review highlights the complex role of biomechanics in OA and showcase numerous innovative and outstanding contributions to the field. Exciting cross-disciplinary efforts integrating computational modeling, mobile sensors, and machine learning methods show great promise for streamlining in vivo multi-scale biomechanics workflows and are expected to underpin future breakthroughs in the understanding and treatment of biomechanics in OA.",
keywords = "Biomechanics, Cartilage, Computational modeling, Gait, Machine learning",
author = "Diamond, {Laura E.} and Tamara Grant and Uhlrich, {Scott D.}",
note = "Funding Information: The authors wish to acknowledge the Osteoarthritis Research Society International (OARSI) for the invitation to present this review at the 2023 annual meeting. L.D. is supported by a National Health and Medical Research Council (NHMRC) Investigator Grant Emerging Leadership Level 1 (#2017012). S.U. is supported by the Wu Tsai Human Performance Alliance and the US National Institutes of Health (1P41EB027060-01A1). L.D. and T.G. performed the literature search, selected the articles, and extracted data. L.D. and S.U. identified themes, summarized results, and wrote the manuscript. All authors approved the final version of the manuscript. L.D. on behalf of all authors, takes responsibility for the integrity of the work, from inception to manuscript. The authors have no conflicts of interest. Funding Information: The authors wish to acknowledge the Osteoarthritis Research Society International (OARSI) for the invitation to present this review at the 2023 annual meeting. L.D. is supported by a National Health and Medical Research Council (NHMRC) Investigator Grant Emerging Leadership Level 1 (#2017012). S.U. is supported by the Wu Tsai Human Performance Alliance and the US National Institutes of Health (1P41EB027060-01A1). Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2024",
month = feb,
doi = "10.1016/j.joca.2023.11.015",
language = "English",
volume = "32",
pages = "138--147",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
publisher = "W.B. Saunders Ltd",
number = "2",
}