Overview of hyphenated techniques using an ICP-MS detector with an emphasis on extraction techniques for measurement of metalloids by HPLC-ICPMS

William Maher, Michael Ellwood, Simon Foster, Rajani Jagtap, George Raber

    Research output: Contribution to journalArticle

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    Abstract

    In this review we present an overview of hyphenated techniques using an ICPMS detector with an emphasis on extraction techniques for the measurement of metalloids by high pressure liquid chromatographyâ¿¿inductively plasma mass spectrometry (HPLC-ICPMS). Five modes of using hyphenated ICPMS systems; HPLC-ICPMS, HPLC-hydride generation-ICPMS, Cryogenic trapping ICPMS, in-situ Cryogenic trapping ICPMS and Gas Chromatography-ICPMS are described together with their application for the measurement of arsenic, selenium, mercury and antimony species. Two classes of metalloid species are described; "Easy to extract species," stable species existing as discrete molecules or relatively weakly bound to cellular constituents, and Hard to extract species," unstable species that dissociate on extraction and species incorporated within cellular constituents such as proteins. Measurements described include, arsenic species: arsenobetaine, arsenoribosides, arsenic bound to lipids and phytochelatins and other minor arsenic species including thioarsenic species. Selenium species: selenocysteine and selenomethionine, Se-methyl selenomethionine, Se-methyl selenocysteine, y-glutamyl-Semethylselenocysteine, dimethylselenide and dimethyldiselenide. Mercury species: inorganic Hg and methyl Hg. Antimony species: antimonite and antimonate. Germaniumspecies: inorganic. Extraction methods are discussed in terms of their extraction efficiencies, stability of species and artifact formation.
    Original languageEnglish
    Pages (from-to)15-31
    Number of pages17
    JournalMicrochemical Journal
    Volume105
    Issue numberNovember 2012
    DOIs
    Publication statusPublished - 2012

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    Metalloids
    Arsenic
    Mass spectrometry
    Selenomethionine
    Detectors
    Plasmas
    Antimony
    Liquids
    Selenium
    Mercury
    Cryogenics
    Phytochelatins
    Selenocysteine
    Hydrides
    Gas chromatography
    Lipids
    Molecules
    Proteins

    Cite this

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    abstract = "In this review we present an overview of hyphenated techniques using an ICPMS detector with an emphasis on extraction techniques for the measurement of metalloids by high pressure liquid chromatography{\^a}¿¿inductively plasma mass spectrometry (HPLC-ICPMS). Five modes of using hyphenated ICPMS systems; HPLC-ICPMS, HPLC-hydride generation-ICPMS, Cryogenic trapping ICPMS, in-situ Cryogenic trapping ICPMS and Gas Chromatography-ICPMS are described together with their application for the measurement of arsenic, selenium, mercury and antimony species. Two classes of metalloid species are described; {"}Easy to extract species,{"} stable species existing as discrete molecules or relatively weakly bound to cellular constituents, and Hard to extract species,{"} unstable species that dissociate on extraction and species incorporated within cellular constituents such as proteins. Measurements described include, arsenic species: arsenobetaine, arsenoribosides, arsenic bound to lipids and phytochelatins and other minor arsenic species including thioarsenic species. Selenium species: selenocysteine and selenomethionine, Se-methyl selenomethionine, Se-methyl selenocysteine, y-glutamyl-Semethylselenocysteine, dimethylselenide and dimethyldiselenide. Mercury species: inorganic Hg and methyl Hg. Antimony species: antimonite and antimonate. Germaniumspecies: inorganic. Extraction methods are discussed in terms of their extraction efficiencies, stability of species and artifact formation.",
    keywords = "Metalloids, Species, Plants and animal tissues, Hyphenated ICPMS, HPLC{\^a}¿¿ICPMS, Extraction",
    author = "William Maher and Michael Ellwood and Simon Foster and Rajani Jagtap and George Raber",
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    language = "English",
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    Overview of hyphenated techniques using an ICP-MS detector with an emphasis on extraction techniques for measurement of metalloids by HPLC-ICPMS. / Maher, William; Ellwood, Michael; Foster, Simon; Jagtap, Rajani; Raber, George.

    In: Microchemical Journal, Vol. 105, No. November 2012, 2012, p. 15-31.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Overview of hyphenated techniques using an ICP-MS detector with an emphasis on extraction techniques for measurement of metalloids by HPLC-ICPMS

    AU - Maher, William

    AU - Ellwood, Michael

    AU - Foster, Simon

    AU - Jagtap, Rajani

    AU - Raber, George

    PY - 2012

    Y1 - 2012

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    AB - In this review we present an overview of hyphenated techniques using an ICPMS detector with an emphasis on extraction techniques for the measurement of metalloids by high pressure liquid chromatographyâ¿¿inductively plasma mass spectrometry (HPLC-ICPMS). Five modes of using hyphenated ICPMS systems; HPLC-ICPMS, HPLC-hydride generation-ICPMS, Cryogenic trapping ICPMS, in-situ Cryogenic trapping ICPMS and Gas Chromatography-ICPMS are described together with their application for the measurement of arsenic, selenium, mercury and antimony species. Two classes of metalloid species are described; "Easy to extract species," stable species existing as discrete molecules or relatively weakly bound to cellular constituents, and Hard to extract species," unstable species that dissociate on extraction and species incorporated within cellular constituents such as proteins. Measurements described include, arsenic species: arsenobetaine, arsenoribosides, arsenic bound to lipids and phytochelatins and other minor arsenic species including thioarsenic species. Selenium species: selenocysteine and selenomethionine, Se-methyl selenomethionine, Se-methyl selenocysteine, y-glutamyl-Semethylselenocysteine, dimethylselenide and dimethyldiselenide. Mercury species: inorganic Hg and methyl Hg. Antimony species: antimonite and antimonate. Germaniumspecies: inorganic. Extraction methods are discussed in terms of their extraction efficiencies, stability of species and artifact formation.

    KW - Metalloids

    KW - Species

    KW - Plants and animal tissues

    KW - Hyphenated ICPMS

    KW - HPLCâ¿¿ICPMS

    KW - Extraction

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    DO - 10.1016/j.microc.2012.03.017

    M3 - Article

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    EP - 31

    JO - Microchemical Journal

    JF - Microchemical Journal

    SN - 0026-265X

    IS - November 2012

    ER -