Paracetamol and analgesic nephropathy: Are you kidneying me?

Freya Waddington, Mark NAUNTON, Jackson THOMAS

Research output: Contribution to journalArticle

3 Citations (Scopus)
2 Downloads (Pure)

Abstract

Introduction: Analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years, leading to significant impairment of renal function. The observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led to the initial recognition of the nephrotoxicity from the use of analgesics. Phenacetin was subsequently exclusively blamed for this disease. However, the role of a single analgesic as a sole cause of analgesic nephropathy was challenged, and a number of researchers have since attempted to determine the extent of involvement of other analgesics including nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, and paracetamol.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalInternational Medical Case Reports Journal
Volume8
DOIs
Publication statusPublished - 2014

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Acetaminophen
Analgesics
Phenacetin
Aspirin
Renal Insufficiency
Anti-Inflammatory Agents
Research Personnel
Observation
Kidney
Pharmaceutical Preparations

Cite this

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title = "Paracetamol and analgesic nephropathy: Are you kidneying me?",
abstract = "Introduction: Analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years, leading to significant impairment of renal function. The observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led to the initial recognition of the nephrotoxicity from the use of analgesics. Phenacetin was subsequently exclusively blamed for this disease. However, the role of a single analgesic as a sole cause of analgesic nephropathy was challenged, and a number of researchers have since attempted to determine the extent of involvement of other analgesics including nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, and paracetamol.",
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Paracetamol and analgesic nephropathy: Are you kidneying me? / Waddington, Freya; NAUNTON, Mark; THOMAS, Jackson.

In: International Medical Case Reports Journal, Vol. 8, 2014, p. 1-5.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Paracetamol and analgesic nephropathy: Are you kidneying me?

AU - Waddington, Freya

AU - NAUNTON, Mark

AU - THOMAS, Jackson

PY - 2014

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N2 - Introduction: Analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years, leading to significant impairment of renal function. The observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led to the initial recognition of the nephrotoxicity from the use of analgesics. Phenacetin was subsequently exclusively blamed for this disease. However, the role of a single analgesic as a sole cause of analgesic nephropathy was challenged, and a number of researchers have since attempted to determine the extent of involvement of other analgesics including nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, and paracetamol.

AB - Introduction: Analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years, leading to significant impairment of renal function. The observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led to the initial recognition of the nephrotoxicity from the use of analgesics. Phenacetin was subsequently exclusively blamed for this disease. However, the role of a single analgesic as a sole cause of analgesic nephropathy was challenged, and a number of researchers have since attempted to determine the extent of involvement of other analgesics including nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, and paracetamol.

KW - Kidney

KW - Nephropathy

KW - Paracetamol

KW - Phenacetin

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