Context: The invasive cane toad (Rhinella marina) has decimated populations of a keystone predator, the yellow-spotted monitor (Varanus panoptes), causing trophic cascades in Australian animal communities. Paradoxically, some V. panoptes populations coexist with toads. Demonstrating patterns in heterogeneous population-level impacts could reveal mechanisms that mediate individual effects, and provide managers with the ability to predict future impacts and assist in population recovery. Aims: The aim of the present study was to search for spatial patterns of population resilience of V. panoptes to invasive cane toads. Methods: Published literature, unpublished data, reports and anecdotal information from trained herpetologists were used to test the emerging hypothesis that resilient predator populations are mainly coastal, whereas non-resilient populations are mostly inland. Key results: Post-toad invasion data from 23 V. panoptes populations supported the idea that toad impacts on V. panoptes were heterogeneous; roughly half the populations could be designated as resilient (n = 13) and half as non-resilient (n = 10). Resilient populations had longer times since toad invasion than did non-resilient populations (39 versus 9 years respectively), supporting the idea that some recovery can occur. Non-resilient populations were exclusively inland (n = 10), whereas resilient populations were split between inland (n = 5) and coastal (n = 8) populations. Resilient inland populations, however, were mainly confined to areas in which decades had passed since toad invasion. Conclusions: The findings suggest that coastal V. panoptes populations fare much better than inland populations when it comes to surviving invading cane toads. Implications: Unambiguous recovery of monitor populations remains undemonstrated and will require long-term population monitoring before and after toad invasion.