Parallel adaptation of rabbit populations to myxoma virus

Joel M. Alves, Miguel Carneiro, Jade Y. Cheng, Ana Lemos de Matos, Masmudur M. Rahman, Liisa Loog, Paula F. Campos, Nathan Wales, Anders Eriksson, Andrea Manica, Tanja Strive, Stephen C. Graham, Sandra Afonso, Diana J. Bell, Laura Belmont, Jonathan P. Day, Susan J. Fuller, Stéphane Marchandeau, William J. Palmer, Guillaume Queney & 8 others Alison K. Surridge, Filipe G. Vieira, Grant McFadden, Rasmus Nielsen, M. Thomas P. Gilbert, Pedro J. Esteves, Nuno Ferrand, Francis M. Jiggins

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.

Original languageEnglish
Pages (from-to)1319-1326
Number of pages8
JournalScience
Volume363
Issue number6433
DOIs
Publication statusPublished - 22 Mar 2019
Externally publishedYes

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Myxoma virus
Rabbits
Exome
Viral Genes
Pandemics
Interferons
Population
France
Antiviral Agents
Immunity
Proteins
Alleles
Genes

Cite this

Alves, J. M., Carneiro, M., Cheng, J. Y., de Matos, A. L., Rahman, M. M., Loog, L., ... Jiggins, F. M. (2019). Parallel adaptation of rabbit populations to myxoma virus. Science, 363(6433), 1319-1326. https://doi.org/10.1126/science.aau7285
Alves, Joel M. ; Carneiro, Miguel ; Cheng, Jade Y. ; de Matos, Ana Lemos ; Rahman, Masmudur M. ; Loog, Liisa ; Campos, Paula F. ; Wales, Nathan ; Eriksson, Anders ; Manica, Andrea ; Strive, Tanja ; Graham, Stephen C. ; Afonso, Sandra ; Bell, Diana J. ; Belmont, Laura ; Day, Jonathan P. ; Fuller, Susan J. ; Marchandeau, Stéphane ; Palmer, William J. ; Queney, Guillaume ; Surridge, Alison K. ; Vieira, Filipe G. ; McFadden, Grant ; Nielsen, Rasmus ; Gilbert, M. Thomas P. ; Esteves, Pedro J. ; Ferrand, Nuno ; Jiggins, Francis M. / Parallel adaptation of rabbit populations to myxoma virus. In: Science. 2019 ; Vol. 363, No. 6433. pp. 1319-1326.
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abstract = "In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.",
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Alves, JM, Carneiro, M, Cheng, JY, de Matos, AL, Rahman, MM, Loog, L, Campos, PF, Wales, N, Eriksson, A, Manica, A, Strive, T, Graham, SC, Afonso, S, Bell, DJ, Belmont, L, Day, JP, Fuller, SJ, Marchandeau, S, Palmer, WJ, Queney, G, Surridge, AK, Vieira, FG, McFadden, G, Nielsen, R, Gilbert, MTP, Esteves, PJ, Ferrand, N & Jiggins, FM 2019, 'Parallel adaptation of rabbit populations to myxoma virus', Science, vol. 363, no. 6433, pp. 1319-1326. https://doi.org/10.1126/science.aau7285

Parallel adaptation of rabbit populations to myxoma virus. / Alves, Joel M.; Carneiro, Miguel; Cheng, Jade Y.; de Matos, Ana Lemos; Rahman, Masmudur M.; Loog, Liisa; Campos, Paula F.; Wales, Nathan; Eriksson, Anders; Manica, Andrea; Strive, Tanja; Graham, Stephen C.; Afonso, Sandra; Bell, Diana J.; Belmont, Laura; Day, Jonathan P.; Fuller, Susan J.; Marchandeau, Stéphane; Palmer, William J.; Queney, Guillaume; Surridge, Alison K.; Vieira, Filipe G.; McFadden, Grant; Nielsen, Rasmus; Gilbert, M. Thomas P.; Esteves, Pedro J.; Ferrand, Nuno; Jiggins, Francis M.

In: Science, Vol. 363, No. 6433, 22.03.2019, p. 1319-1326.

Research output: Contribution to journalArticle

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T1 - Parallel adaptation of rabbit populations to myxoma virus

AU - Alves, Joel M.

AU - Carneiro, Miguel

AU - Cheng, Jade Y.

AU - de Matos, Ana Lemos

AU - Rahman, Masmudur M.

AU - Loog, Liisa

AU - Campos, Paula F.

AU - Wales, Nathan

AU - Eriksson, Anders

AU - Manica, Andrea

AU - Strive, Tanja

AU - Graham, Stephen C.

AU - Afonso, Sandra

AU - Bell, Diana J.

AU - Belmont, Laura

AU - Day, Jonathan P.

AU - Fuller, Susan J.

AU - Marchandeau, Stéphane

AU - Palmer, William J.

AU - Queney, Guillaume

AU - Surridge, Alison K.

AU - Vieira, Filipe G.

AU - McFadden, Grant

AU - Nielsen, Rasmus

AU - Gilbert, M. Thomas P.

AU - Esteves, Pedro J.

AU - Ferrand, Nuno

AU - Jiggins, Francis M.

PY - 2019/3/22

Y1 - 2019/3/22

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U2 - 10.1126/science.aau7285

DO - 10.1126/science.aau7285

M3 - Article

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JO - The Scientific monthly

JF - The Scientific monthly

SN - 0036-8075

IS - 6433

ER -

Alves JM, Carneiro M, Cheng JY, de Matos AL, Rahman MM, Loog L et al. Parallel adaptation of rabbit populations to myxoma virus. Science. 2019 Mar 22;363(6433):1319-1326. https://doi.org/10.1126/science.aau7285