Pathogenesis and molecular biology of a transmissible tumor in the Tasmanian Devil

Hannah Bender, Jenny Marshall Graves, Janine DEAKIN

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    The emergence of a fatal transmissible cancer known as devil facial tumor disease (DFTD) is threatening the iconic Tasmanian devil with extinction in the wild within the next few decades. Since the first report of the disease in 1996, DFTD has spread to over 85% of the devils’ distribution and dramatically reduced devil numbers. Research into DFTD has focused on gaining a deeper understanding of the disease on multiple levels, including an accurate assessment of the tissue origin of the tumor, elucidation of how the tumor evades immune detection, and determination of how the tumor is transmitted between individuals and how it is evolving as it spreads through the population. Knowledge gained from these studies has important implications for DFTD management and devil conservation.
    Original languageEnglish
    Pages (from-to)165-187
    Number of pages23
    JournalAnnual Review of Animal Biosciences
    Volume2
    DOIs
    Publication statusPublished - 2014

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    molecular biology
    Molecular Biology
    pathogenesis
    neoplasms
    Neoplasms
    Disease Management
    disease control
    extinction
    Research
    Population

    Cite this

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    abstract = "The emergence of a fatal transmissible cancer known as devil facial tumor disease (DFTD) is threatening the iconic Tasmanian devil with extinction in the wild within the next few decades. Since the first report of the disease in 1996, DFTD has spread to over 85{\%} of the devils’ distribution and dramatically reduced devil numbers. Research into DFTD has focused on gaining a deeper understanding of the disease on multiple levels, including an accurate assessment of the tissue origin of the tumor, elucidation of how the tumor evades immune detection, and determination of how the tumor is transmitted between individuals and how it is evolving as it spreads through the population. Knowledge gained from these studies has important implications for DFTD management and devil conservation.",
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    Pathogenesis and molecular biology of a transmissible tumor in the Tasmanian Devil. / Bender, Hannah; Marshall Graves, Jenny; DEAKIN, Janine.

    In: Annual Review of Animal Biosciences, Vol. 2, 2014, p. 165-187.

    Research output: Contribution to journalArticle

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