TY - JOUR
T1 - Patterns of brain activation during craving in heroin dependents successfully treated by methadone maintenance and abstinence-based treatments
AU - Tabatabaei-Jafari, Hossein
AU - Studies, Institute
AU - Studies, Institute
AU - Studies, Institute
AU - Studies, Institute
AU - Studies, Institute
AU - Studies, Institute
AU - Studies, Institute
PY - 2014
Y1 - 2014
N2 - Objective: Abstinence-based therapy (ABT) and methadone maintenance therapy (MMT) are common methods of treatment in heroin dependence as both suppress subjective feeling of drug craving. However, it is not clear whether the neural basis of craving suppression is similar in both types of treatments. In this study, we compared brain activation during pictorial presentation of heroin-related cues in ABT and MMT groups to understand the neural basis of drug craving in these groups., Methods: Three groups of subjects (successful ABT and MMT clients and healthy control) underwent functionalmagnetic resonance imaging, while heroin-related cues and neutral cues were presented to them. In addition, subjective cue-elicited craving has been measured using drug drive questionnaire before and after imaging., Result: Self-report of craving was not different between ABT and MMT groups before and after scanning. Anterior cingulate cortex and inferior frontal gyrus showed higher activations in ABT than in healthy control. Inferior frontal gyrus and superior temporal gyrus showed higher activity in ABT than in MMT. Lingual gyrus and cerebellum showed higher activity in MMT than in healthy control. Conclusions: Heroin avoidance may be achieved by MMT or ABT; however, the neuralmechanism underlying these therapeutic methods differs.
AB - Objective: Abstinence-based therapy (ABT) and methadone maintenance therapy (MMT) are common methods of treatment in heroin dependence as both suppress subjective feeling of drug craving. However, it is not clear whether the neural basis of craving suppression is similar in both types of treatments. In this study, we compared brain activation during pictorial presentation of heroin-related cues in ABT and MMT groups to understand the neural basis of drug craving in these groups., Methods: Three groups of subjects (successful ABT and MMT clients and healthy control) underwent functionalmagnetic resonance imaging, while heroin-related cues and neutral cues were presented to them. In addition, subjective cue-elicited craving has been measured using drug drive questionnaire before and after imaging., Result: Self-report of craving was not different between ABT and MMT groups before and after scanning. Anterior cingulate cortex and inferior frontal gyrus showed higher activations in ABT than in healthy control. Inferior frontal gyrus and superior temporal gyrus showed higher activity in ABT than in MMT. Lingual gyrus and cerebellum showed higher activity in MMT than in healthy control. Conclusions: Heroin avoidance may be achieved by MMT or ABT; however, the neuralmechanism underlying these therapeutic methods differs.
KW - Abstinence
KW - Craving
KW - Functional magnetic resonanceimaging
KW - Heroin
KW - Methadone
UR - http://www.scopus.com/inward/record.url?scp=84898722029&partnerID=8YFLogxK
U2 - 10.1097/ADM.0000000000000022
DO - 10.1097/ADM.0000000000000022
M3 - Article
C2 - 24637623
AN - SCOPUS:84898722029
SN - 1932-0620
VL - 8
SP - 123
EP - 129
JO - Journal of Addiction Medicine
JF - Journal of Addiction Medicine
IS - 2
ER -