Abstract
Peracetylated β-cyclodextrin has been employed as a macrocyclic additive to enhance the enantiomeric ratio E and reaction rate in Pseudomonas cepacia lipase (PSL)-catalyzed enantioselective transesterification of 1-(2-furyl)ethanol in organic solvents. The beneficial action of the cyclodextrin used as a regulator of lipase was tentatively interpreted as increasing the conformational flexibility of the enzyme and undergoing host-guest complexation with the product, thereby preventing product inhibition and leading to an enhancement of the enantiomeric ratio E and the reaction rate. The effect of the organic solvent on the present cyclodextrin-mediated enzymatic transesterification has been studied.
| Original language | English |
|---|---|
| Pages (from-to) | 2761-2766 |
| Number of pages | 6 |
| Journal | Tetrahedron Asymmetry |
| Volume | 12 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 30 Oct 2001 |
| Externally published | Yes |