Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients

C Della Vedova, Stuart CATHCART, A Dohnalek, Vanessa Lee, Mark Hutchinson, Maarten Immink, John Hayball

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    BACKGROUND: Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH. OBJECTIVES: To determine the role of peripheral cytokines and genetic factors in the development of CTTH. METHODS: A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age. Results: Levels of interleukin (IL)-1ß were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in the IL-1B gene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1ß gene. Conclusions: These findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation. ©2013 Pulsus Group Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)301-306
    Number of pages6
    JournalPain Research and Management
    Volume18
    Issue number6
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Tension-Type Headache
    Headache Disorders
    Interleukin-1
    Cytokines
    Single Nucleotide Polymorphism
    Pathology
    Somatoform Disorders
    Interleukin-18
    Interleukins
    Chronic Pain
    Restriction Fragment Length Polymorphisms
    Genes
    Pulse
    Healthy Volunteers

    Cite this

    Della Vedova, C., CATHCART, S., Dohnalek, A., Lee, V., Hutchinson, M., Immink, M., & Hayball, J. (2013). Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients. Pain Research and Management, 18(6), 301-306. https://doi.org/10.1155/2013/796161
    Della Vedova, C ; CATHCART, Stuart ; Dohnalek, A ; Lee, Vanessa ; Hutchinson, Mark ; Immink, Maarten ; Hayball, John. / Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients. In: Pain Research and Management. 2013 ; Vol. 18, No. 6. pp. 301-306.
    @article{d22b5e467a804fde9b8d4828a417dc02,
    title = "Peripheral interleukin-1{\ss} levels are elevated in chronic tension-type headache patients",
    abstract = "BACKGROUND: Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH. OBJECTIVES: To determine the role of peripheral cytokines and genetic factors in the development of CTTH. METHODS: A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age. Results: Levels of interleukin (IL)-1{\ss} were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in the IL-1B gene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1{\ss} gene. Conclusions: These findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation. {\circledC}2013 Pulsus Group Inc. All rights reserved.",
    author = "{Della Vedova}, C and Stuart CATHCART and A Dohnalek and Vanessa Lee and Mark Hutchinson and Maarten Immink and John Hayball",
    year = "2013",
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    Della Vedova, C, CATHCART, S, Dohnalek, A, Lee, V, Hutchinson, M, Immink, M & Hayball, J 2013, 'Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients', Pain Research and Management, vol. 18, no. 6, pp. 301-306. https://doi.org/10.1155/2013/796161

    Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients. / Della Vedova, C; CATHCART, Stuart; Dohnalek, A; Lee, Vanessa; Hutchinson, Mark; Immink, Maarten; Hayball, John.

    In: Pain Research and Management, Vol. 18, No. 6, 2013, p. 301-306.

    Research output: Contribution to journalArticle

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    T1 - Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients

    AU - Della Vedova, C

    AU - CATHCART, Stuart

    AU - Dohnalek, A

    AU - Lee, Vanessa

    AU - Hutchinson, Mark

    AU - Immink, Maarten

    AU - Hayball, John

    PY - 2013

    Y1 - 2013

    N2 - BACKGROUND: Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH. OBJECTIVES: To determine the role of peripheral cytokines and genetic factors in the development of CTTH. METHODS: A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age. Results: Levels of interleukin (IL)-1ß were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in the IL-1B gene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1ß gene. Conclusions: These findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation. ©2013 Pulsus Group Inc. All rights reserved.

    AB - BACKGROUND: Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH. OBJECTIVES: To determine the role of peripheral cytokines and genetic factors in the development of CTTH. METHODS: A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age. Results: Levels of interleukin (IL)-1ß were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in the IL-1B gene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1ß gene. Conclusions: These findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation. ©2013 Pulsus Group Inc. All rights reserved.

    U2 - 10.1155/2013/796161

    DO - 10.1155/2013/796161

    M3 - Article

    VL - 18

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    EP - 306

    JO - Pain Research and Management

    JF - Pain Research and Management

    SN - 1203-6765

    IS - 6

    ER -

    Della Vedova C, CATHCART S, Dohnalek A, Lee V, Hutchinson M, Immink M et al. Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients. Pain Research and Management. 2013;18(6):301-306. https://doi.org/10.1155/2013/796161