Personalizing health care: Feasibility and future implications

Brian Godman, Alexander Finlayson, Parneet Cheema, Eva Zebedin-Brandl, Iñaki Gutiérrez-Ibarluzea, Jan Jones, Rickard Malmström, Elina Asola, Christoph Baumgärtel, Marion Bennie, Iain Bishop, Anna Bucsics, Stephen Campbell, Eduardo Diogene, Alessandra Ferrairo, Jurij Fürst, Kristina Garuoliene, Miguel Gomes, Katharine Harris, Alan HaycoxHarald Herholz, Krystyna Hviding, Saira Jan, Marija Kalaba, Christina Kvalheim, Ott Laius, Sven-Åke Lööv, Kamila Malinowska, Andrew Martin, Laura McCullagh, Fredrik Nilsson, Ken Paterson, Ulrich Schwabe, Gisbert Selke, Catherine Sermet, Steven Simoens, Dominik Tomek, Vera Vlahovic-Palcevski, Luka Voncina, Magdalena Wladysiuk, Menno Van Woerkom, Durhane Wong-Rieger, Corrine Zara, Raghib Ali, Lars Gustafsson

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved. There are also concerns that advice for tests has been reversed, current tests can be costly, there is fragmentation of funding of care, and companies may seek high prices for new targeted drugs. There is a need to integrate current knowledge from a payer's perspective to provide future guidance. Multiple findings including general considerations; influence of pharmacogenomics on response and toxicity of drug therapies; value of biomarker tests; limitations and costs of tests; and potentially high acquisition costs of new targeted therapies help to give guidance on potential ways forward for all stakeholder groups. Overall, personalized medicine has the potential to revolutionize care. However, current challenges and concerns need to be addressed to enhance its uptake and funding to benefit patients
Original languageEnglish
Article number179
Pages (from-to)1-23
Number of pages23
JournalBMC Medicine
Volume11
DOIs
Publication statusPublished - 2013
Externally publishedYes

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  • Cite this

    Godman, B., Finlayson, A., Cheema, P., Zebedin-Brandl, E., Gutiérrez-Ibarluzea, I., Jones, J., Malmström, R., Asola, E., Baumgärtel, C., Bennie, M., Bishop, I., Bucsics, A., Campbell, S., Diogene, E., Ferrairo, A., Fürst, J., Garuoliene, K., Gomes, M., Harris, K., ... Gustafsson, L. (2013). Personalizing health care: Feasibility and future implications. BMC Medicine, 11, 1-23. [179]. https://doi.org/10.1186/1741-7015-11-179