Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study

Johan Bagge, Jamie GAIDA, Patrik Danielson, Hakan Alfredson, Sture Forsgren

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Physical activity affects the pain symptoms for Achilles tendinosis patients. Brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF-α) and their receptors have been detected in human Achilles tendon. This pilot study aimed to compare serum BDNF and soluble tumor necrosis factor receptor I (sTNFRI) levels in Achilles tendinosis patients and healthy controls and to examine the influence of physical activity, and BMI and gender, on these levels. Physical activity was measured with a validated questionnaire, total physical activity being the parameter analyzed. Physical activity was strongly correlated with BDNF among tendinosis women [Spearman's rho (ρ)=0.90, P<0.01] but not among control women (ρ=−0.08, P=0.83), or among tendinosis and control men. Physical activity was significantly correlated with sTNFRI in the entire tendinosis group and among tendinosis men (ρ=0.65, P=0.01), but not in the entire control group or among control men (ρ=0.04, P=0.91). Thus, the physical activity pattern is related to the TNF and BDNF systems for tendinosis patients but not controls, the relationship being gender dependent. This is new information concerning the relationship between physical activity and Achilles tendinosis, which may be related to pain for the patients. This aspect should be further evaluated using larger patient materials.
Original languageEnglish
Pages (from-to)e430-e438
Number of pages8
JournalScandinavian Journal of Medicine and Science in Sports
Volume21
Issue number6
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Tendinopathy
Exercise
Pain
Brain-Derived Neurotrophic Factor
Tumor Necrosis Factor Receptors
Achilles Tendon
Tumor Necrosis Factor-alpha
Control Groups
Serum

Cite this

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title = "Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study",
abstract = "Physical activity affects the pain symptoms for Achilles tendinosis patients. Brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF-α) and their receptors have been detected in human Achilles tendon. This pilot study aimed to compare serum BDNF and soluble tumor necrosis factor receptor I (sTNFRI) levels in Achilles tendinosis patients and healthy controls and to examine the influence of physical activity, and BMI and gender, on these levels. Physical activity was measured with a validated questionnaire, total physical activity being the parameter analyzed. Physical activity was strongly correlated with BDNF among tendinosis women [Spearman's rho (ρ)=0.90, P<0.01] but not among control women (ρ=−0.08, P=0.83), or among tendinosis and control men. Physical activity was significantly correlated with sTNFRI in the entire tendinosis group and among tendinosis men (ρ=0.65, P=0.01), but not in the entire control group or among control men (ρ=0.04, P=0.91). Thus, the physical activity pattern is related to the TNF and BDNF systems for tendinosis patients but not controls, the relationship being gender dependent. This is new information concerning the relationship between physical activity and Achilles tendinosis, which may be related to pain for the patients. This aspect should be further evaluated using larger patient materials.",
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Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study. / Bagge, Johan; GAIDA, Jamie; Danielson, Patrik; Alfredson, Hakan; Forsgren, Sture.

In: Scandinavian Journal of Medicine and Science in Sports, Vol. 21, No. 6, 2011, p. e430-e438.

Research output: Contribution to journalArticle

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