Plasma homocysteine in an Australian population sample

Paul D. Roach, Nenad NAUMOVSKI, Barbara Blades, Peter Lewis

Research output: Contribution to conference (non-published works)Abstract

Abstract

Objectives: To determine the plasma homocysteine concentrations in a sample of the New South Wales Central Coast population and relate them to their red cell folate and plasma vitamin B12 levels. Methods: Plasma samples were collected from 387 subjects (213 females; 174 males), with a mean age of 54.6 ± 15.5 years (mean ± sd) (females 54.2 ± 15.3; males 55.2 ± 15.8). Homocysteine was measured by HPLC. Red cell folate and vitamin B12 were measured by immunoassay. Results: The mean homocysteine concentrations were 10.3 ± 5.2 µM for the whole population sample, 10.0 ± 5.7 µM for the females and 10.6 ± 4.5 µM for the males. Notably, 14% of subjects had plasma homocysteine concentrations higher than 14 µM and 40% had concentrations higher than 10 µM. There was a positive correlation between the homocysteine concentration and age (r = 0.160; p = 0.002), a negative correlation between the homocysteine concentration and red cell folate (r = -0.247; p<0.001) and a negative .correlation between the homocysteine concentration and plasma vitamin B12 levels (r = -0.230; p<0.001). Conclusions: This sample of 387 subjects had plasma homocysteine concentrations similar to other population samples with 40% having levels above the recommended 10 µM threshold. Increasing age, decreased red cell folate and decreased plasma vitamin B12 appeared to be factors contributing to increased plasma homocysteine concentrations in this population sample.
Original languageEnglish
Pages122
Number of pages1
Publication statusPublished - 2003
Externally publishedYes
EventXIII International Symposium on Atherosclerosis - Kyoto, Japan
Duration: 28 Sep 20032 Oct 2003

Conference

ConferenceXIII International Symposium on Atherosclerosis
CountryJapan
CityKyoto
Period28/09/032/10/03

Fingerprint

Homocysteine
Vitamin B 12
Population
Folic Acid
New South Wales
Immunoassay
High Pressure Liquid Chromatography

Cite this

Roach, P. D., NAUMOVSKI, N., Blades, B., & Lewis, P. (2003). Plasma homocysteine in an Australian population sample. 122. Abstract from XIII International Symposium on Atherosclerosis, Kyoto, Japan.
Roach, Paul D. ; NAUMOVSKI, Nenad ; Blades, Barbara ; Lewis, Peter. / Plasma homocysteine in an Australian population sample. Abstract from XIII International Symposium on Atherosclerosis, Kyoto, Japan.1 p.
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abstract = "Objectives: To determine the plasma homocysteine concentrations in a sample of the New South Wales Central Coast population and relate them to their red cell folate and plasma vitamin B12 levels. Methods: Plasma samples were collected from 387 subjects (213 females; 174 males), with a mean age of 54.6 ± 15.5 years (mean ± sd) (females 54.2 ± 15.3; males 55.2 ± 15.8). Homocysteine was measured by HPLC. Red cell folate and vitamin B12 were measured by immunoassay. Results: The mean homocysteine concentrations were 10.3 ± 5.2 µM for the whole population sample, 10.0 ± 5.7 µM for the females and 10.6 ± 4.5 µM for the males. Notably, 14{\%} of subjects had plasma homocysteine concentrations higher than 14 µM and 40{\%} had concentrations higher than 10 µM. There was a positive correlation between the homocysteine concentration and age (r = 0.160; p = 0.002), a negative correlation between the homocysteine concentration and red cell folate (r = -0.247; p<0.001) and a negative .correlation between the homocysteine concentration and plasma vitamin B12 levels (r = -0.230; p<0.001). Conclusions: This sample of 387 subjects had plasma homocysteine concentrations similar to other population samples with 40{\%} having levels above the recommended 10 µM threshold. Increasing age, decreased red cell folate and decreased plasma vitamin B12 appeared to be factors contributing to increased plasma homocysteine concentrations in this population sample.",
author = "Roach, {Paul D.} and Nenad NAUMOVSKI and Barbara Blades and Peter Lewis",
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language = "English",
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Roach, PD, NAUMOVSKI, N, Blades, B & Lewis, P 2003, 'Plasma homocysteine in an Australian population sample' XIII International Symposium on Atherosclerosis, Kyoto, Japan, 28/09/03 - 2/10/03, pp. 122.

Plasma homocysteine in an Australian population sample. / Roach, Paul D.; NAUMOVSKI, Nenad; Blades, Barbara; Lewis, Peter.

2003. 122 Abstract from XIII International Symposium on Atherosclerosis, Kyoto, Japan.

Research output: Contribution to conference (non-published works)Abstract

TY - CONF

T1 - Plasma homocysteine in an Australian population sample

AU - Roach, Paul D.

AU - NAUMOVSKI, Nenad

AU - Blades, Barbara

AU - Lewis, Peter

PY - 2003

Y1 - 2003

N2 - Objectives: To determine the plasma homocysteine concentrations in a sample of the New South Wales Central Coast population and relate them to their red cell folate and plasma vitamin B12 levels. Methods: Plasma samples were collected from 387 subjects (213 females; 174 males), with a mean age of 54.6 ± 15.5 years (mean ± sd) (females 54.2 ± 15.3; males 55.2 ± 15.8). Homocysteine was measured by HPLC. Red cell folate and vitamin B12 were measured by immunoassay. Results: The mean homocysteine concentrations were 10.3 ± 5.2 µM for the whole population sample, 10.0 ± 5.7 µM for the females and 10.6 ± 4.5 µM for the males. Notably, 14% of subjects had plasma homocysteine concentrations higher than 14 µM and 40% had concentrations higher than 10 µM. There was a positive correlation between the homocysteine concentration and age (r = 0.160; p = 0.002), a negative correlation between the homocysteine concentration and red cell folate (r = -0.247; p<0.001) and a negative .correlation between the homocysteine concentration and plasma vitamin B12 levels (r = -0.230; p<0.001). Conclusions: This sample of 387 subjects had plasma homocysteine concentrations similar to other population samples with 40% having levels above the recommended 10 µM threshold. Increasing age, decreased red cell folate and decreased plasma vitamin B12 appeared to be factors contributing to increased plasma homocysteine concentrations in this population sample.

AB - Objectives: To determine the plasma homocysteine concentrations in a sample of the New South Wales Central Coast population and relate them to their red cell folate and plasma vitamin B12 levels. Methods: Plasma samples were collected from 387 subjects (213 females; 174 males), with a mean age of 54.6 ± 15.5 years (mean ± sd) (females 54.2 ± 15.3; males 55.2 ± 15.8). Homocysteine was measured by HPLC. Red cell folate and vitamin B12 were measured by immunoassay. Results: The mean homocysteine concentrations were 10.3 ± 5.2 µM for the whole population sample, 10.0 ± 5.7 µM for the females and 10.6 ± 4.5 µM for the males. Notably, 14% of subjects had plasma homocysteine concentrations higher than 14 µM and 40% had concentrations higher than 10 µM. There was a positive correlation between the homocysteine concentration and age (r = 0.160; p = 0.002), a negative correlation between the homocysteine concentration and red cell folate (r = -0.247; p<0.001) and a negative .correlation between the homocysteine concentration and plasma vitamin B12 levels (r = -0.230; p<0.001). Conclusions: This sample of 387 subjects had plasma homocysteine concentrations similar to other population samples with 40% having levels above the recommended 10 µM threshold. Increasing age, decreased red cell folate and decreased plasma vitamin B12 appeared to be factors contributing to increased plasma homocysteine concentrations in this population sample.

M3 - Abstract

SP - 122

ER -

Roach PD, NAUMOVSKI N, Blades B, Lewis P. Plasma homocysteine in an Australian population sample. 2003. Abstract from XIII International Symposium on Atherosclerosis, Kyoto, Japan.