Polygenic sex determination in vertebrates – is there any such thing?

Manfred Schartl, Arthur Georges, Jennifer A. Marshall Graves

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Genetic sex determination (SD) in most vertebrates is controlled by a single master sex gene, which ensures a 1:1 sex ratio. However, more complex systems abound, and several have been ascribed to polygenic SD (PSD), in which many genes at different loci interact to produce the sexual phenotype. Here we examine claims for PSD in vertebrates, finding that most constitute transient states during sex chromosome turnover, or aberrant systems in species hybrids. To avoid confusion about terminology, we propose a consistent nomenclature for genetic SD systems.

Original languageEnglish
Pages (from-to)242-250
Number of pages9
JournalTrends in Genetics
Issue number4
Publication statusPublished - 18 Jan 2023


Dive into the research topics of 'Polygenic sex determination in vertebrates – is there any such thing?'. Together they form a unique fingerprint.

Cite this