Polymer monolith-supported dirhodium(II)-catalyzed continuous flow cyclopropanation in capillary format

Frady G. Adly, Ashraf Ghanem

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Herein, the first trial for the miniaturization of the dirhodium(II)-catalyzed cyclopropanation reaction is reported. Rh2(S-tertPTTL)4†was immobilized inside a capillary microreactor on a pyridine-derived monolithic support. The system demonstrated good stability with low leaching rate of the dirhodium(II) catalyst comparable to conventional packed solid support. The Rh2(S-tertPTTL)4-catalyzed cyclopropanation microreaction was carried out under continuous flow conditions generating the cyclopropane product in moderate yield (44%) and excellent diastereoselectivity (>20:1 E:Z dr).
Original languageEnglish
Pages (from-to)852-857
Number of pages6
JournalTetrahedron Letters
Volume57
Issue number8
DOIs
Publication statusPublished - 24 Feb 2016

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