@article{db25454ea59f4d5389742a5ce5cf941f,
title = "Polymer monolith-supported dirhodium(II)-catalyzed continuous flow cyclopropanation in capillary format",
abstract = "Herein, the first trial for the miniaturization of the dirhodium(II)-catalyzed cyclopropanation reaction is reported. Rh2(S-tertPTTL)4†was immobilized inside a capillary microreactor on a pyridine-derived monolithic support. The system demonstrated good stability with low leaching rate of the dirhodium(II) catalyst comparable to conventional packed solid support. The Rh2(S-tertPTTL)4-catalyzed cyclopropanation microreaction was carried out under continuous flow conditions generating the cyclopropane product in moderate yield (44%) and excellent diastereoselectivity (>20:1 E:Z dr).",
keywords = "Cyclopropanation, Dirhodium, Metal-carbenoids, Microreactor, Rh2(S-PTTL)4, Rh2(S-tertPTTL)4, Rh-2(S-PTTL)(4), Rh-2(S-(PTTL)-P-tert)(4)",
author = "Adly, {Frady G.} and Ashraf Ghanem",
note = "Funding Information: The authors gratefully acknowledge the W.J. Weeden scholarships program at the University of Canberra, Australia, for the Ph.D. scholarship offered to Dr. Frady Gamal Adly Gouany. Special acknowledgment is also due to A/Prof. Simon Foster from the Environmental Science Department at the University of Canberra for his assistance in the ICP-MS analysis. The authors would like also to thank Strem Chemicals for licensing and commercializing our catalyst 47 Rh 2 ( S - tert PTTL) 4 † (patent PCT/AU2015/000557) worldwide. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd. All rights reserved. Copyright: Copyright 2016 Elsevier B.V., All rights reserved. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = feb,
day = "24",
doi = "10.1016/j.tetlet.2016.01.010",
language = "English",
volume = "57",
pages = "852--857",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "8",
}