Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs

Julie Arsenault, François Moreau-Bussière, Philippe Reix, Théophile Niyonsenga, Jean Paul Praud

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The postnatal development of ventilatory reflexes originating from bronchopulmonary receptors was assessed in preterm vs. full-term lambs. Ventilation and arterial pressure were repeatedly measured in 10 preterm (gestational age, 132 days) and 7 full-term lambs without sedation from day 1 to day 42. The Hering-Breuer inhibitory reflex (slowly adapting stretch receptors) was assessed by the increase in expiratory time during end-inspiratory occlusion. The pulmonary chemoreflex (C-fiber endings) was assessed by the initial apnea + bradycardia + systemic hypotension and the secondary tachypnea after capsaicin intravenous injection. Results show the following. 1) Premature birth did not modify the maturation of the Hering-Breuer reflex. 2) Whereas a classic pulmonary chemoreflex was observed in the very first hours of life in preterm lambs, the tachypneic component of this reflex was weaker than in full-term lambs on day 1. 3) Premature birth led to a reversed postnatal maturation of this tachypneic response (tendency to increase with postnatal age). Our findings suggest that premature birth in lambs modifies postnatal maturation of the pulmonary chemoreflex.

Original languageEnglish
Pages (from-to)1978-1986
Number of pages9
JournalJournal of Applied Physiology
Volume94
Issue number5
DOIs
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Reflex
Premature Birth
Lung
Tachypnea
Mechanoreceptors
Capsaicin
Apnea
Bradycardia
Intravenous Injections
Hypotension
Gestational Age
Ventilation
Arterial Pressure

Cite this

Arsenault, Julie ; Moreau-Bussière, François ; Reix, Philippe ; Niyonsenga, Théophile ; Praud, Jean Paul. / Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs. In: Journal of Applied Physiology. 2003 ; Vol. 94, No. 5. pp. 1978-1986.
@article{382a8d9061ad4fdab2fe375c6c50ceb1,
title = "Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs",
abstract = "The postnatal development of ventilatory reflexes originating from bronchopulmonary receptors was assessed in preterm vs. full-term lambs. Ventilation and arterial pressure were repeatedly measured in 10 preterm (gestational age, 132 days) and 7 full-term lambs without sedation from day 1 to day 42. The Hering-Breuer inhibitory reflex (slowly adapting stretch receptors) was assessed by the increase in expiratory time during end-inspiratory occlusion. The pulmonary chemoreflex (C-fiber endings) was assessed by the initial apnea + bradycardia + systemic hypotension and the secondary tachypnea after capsaicin intravenous injection. Results show the following. 1) Premature birth did not modify the maturation of the Hering-Breuer reflex. 2) Whereas a classic pulmonary chemoreflex was observed in the very first hours of life in preterm lambs, the tachypneic component of this reflex was weaker than in full-term lambs on day 1. 3) Premature birth led to a reversed postnatal maturation of this tachypneic response (tendency to increase with postnatal age). Our findings suggest that premature birth in lambs modifies postnatal maturation of the pulmonary chemoreflex.",
keywords = "Bronchopulmonary C-fiber endings, Hering-Breuer reflex, Neonatal respiratory control, Pulmonary chemoreflex, Slowly adapting bronchopulmonary stretch receptors",
author = "Julie Arsenault and Fran{\cc}ois Moreau-Bussi{\`e}re and Philippe Reix and Th{\'e}ophile Niyonsenga and Praud, {Jean Paul}",
year = "2003",
doi = "10.1152/japplphysiol.00480.2002",
language = "English",
volume = "94",
pages = "1978--1986",
journal = "Journal of Applied Physiology Respiratory Environmental and Exercise Physiology",
issn = "1522-1601",
publisher = "American Physiological Society",
number = "5",

}

Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs. / Arsenault, Julie; Moreau-Bussière, François; Reix, Philippe; Niyonsenga, Théophile; Praud, Jean Paul.

In: Journal of Applied Physiology, Vol. 94, No. 5, 2003, p. 1978-1986.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs

AU - Arsenault, Julie

AU - Moreau-Bussière, François

AU - Reix, Philippe

AU - Niyonsenga, Théophile

AU - Praud, Jean Paul

PY - 2003

Y1 - 2003

N2 - The postnatal development of ventilatory reflexes originating from bronchopulmonary receptors was assessed in preterm vs. full-term lambs. Ventilation and arterial pressure were repeatedly measured in 10 preterm (gestational age, 132 days) and 7 full-term lambs without sedation from day 1 to day 42. The Hering-Breuer inhibitory reflex (slowly adapting stretch receptors) was assessed by the increase in expiratory time during end-inspiratory occlusion. The pulmonary chemoreflex (C-fiber endings) was assessed by the initial apnea + bradycardia + systemic hypotension and the secondary tachypnea after capsaicin intravenous injection. Results show the following. 1) Premature birth did not modify the maturation of the Hering-Breuer reflex. 2) Whereas a classic pulmonary chemoreflex was observed in the very first hours of life in preterm lambs, the tachypneic component of this reflex was weaker than in full-term lambs on day 1. 3) Premature birth led to a reversed postnatal maturation of this tachypneic response (tendency to increase with postnatal age). Our findings suggest that premature birth in lambs modifies postnatal maturation of the pulmonary chemoreflex.

AB - The postnatal development of ventilatory reflexes originating from bronchopulmonary receptors was assessed in preterm vs. full-term lambs. Ventilation and arterial pressure were repeatedly measured in 10 preterm (gestational age, 132 days) and 7 full-term lambs without sedation from day 1 to day 42. The Hering-Breuer inhibitory reflex (slowly adapting stretch receptors) was assessed by the increase in expiratory time during end-inspiratory occlusion. The pulmonary chemoreflex (C-fiber endings) was assessed by the initial apnea + bradycardia + systemic hypotension and the secondary tachypnea after capsaicin intravenous injection. Results show the following. 1) Premature birth did not modify the maturation of the Hering-Breuer reflex. 2) Whereas a classic pulmonary chemoreflex was observed in the very first hours of life in preterm lambs, the tachypneic component of this reflex was weaker than in full-term lambs on day 1. 3) Premature birth led to a reversed postnatal maturation of this tachypneic response (tendency to increase with postnatal age). Our findings suggest that premature birth in lambs modifies postnatal maturation of the pulmonary chemoreflex.

KW - Bronchopulmonary C-fiber endings

KW - Hering-Breuer reflex

KW - Neonatal respiratory control

KW - Pulmonary chemoreflex

KW - Slowly adapting bronchopulmonary stretch receptors

UR - http://www.scopus.com/inward/record.url?scp=0037404489&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.00480.2002

DO - 10.1152/japplphysiol.00480.2002

M3 - Article

VL - 94

SP - 1978

EP - 1986

JO - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology

JF - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology

SN - 1522-1601

IS - 5

ER -